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$3.86 Million NIH Grant Accelerates Virologist’s Novel Approach in Race to Develop Effective COVID-19 Vaccine

Tuesday, December 15, 2020

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In the midst of the COVID-19 pandemic, as many schools and colleges across the United States implemented plans to provide face-to-face classroom teaching in the fall 2020, the race to develop an effective vaccine intensified, according to Purdue Veterinary Medicine Distinguished Professor of Virology Suresh Mittal. “The availability of an effective vaccine will be vital to protect everyone here in the U.S. and worldwide,” said Dr. Mittal, who is an accomplished vaccine researcher in the College of Veterinary Medicine’s Department of Comparative Pathobiology.

COVID-19 is caused by a coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).  Dr. Mittal is leading a research team that is taking a novel approach to developing an efficient vaccine for COVID-19, and the research received a major boost in the form of a five-year $3.86 million grant from the National Institutes of Health. 

Dr. Mittal and his team work in his lab wearing protective gear
Dr. Suresh Mittal with members of his research team, PhD student Marwa Alhashimi (left), Dr. Ekramy Sayedahmed, a postdoctoral research associate (2nd from right), and PhD student Ahmed Elkashif (far right), as they take out a vial of the cell line from a liquid nitrogen tank to produce the COVID-19 vaccine.

Dr. Mittal’s approach utilizes a harmless form of a common cold-like adenovirus as a vaccine platform. “This platform-based vaccine expresses the important SARS-CoV-2 immunogens that produce an immune response,” Dr. Mittal said. “This type of COVID-19 vaccine provides a balanced antibody and cell-based protection.”

Dr. Mittal said that the COVID-19 vaccine needs to be highly immunogenic because the human immune system does not have an immune memory against this new virus.  His vaccine approach is simple due to the use of a safe version of adenovirus with the capability to induce protective immune responses.

Dr. Mittal is collaborating on the research with Dr. Suresh Kuchipudi, clinical professor and associate director of the Animal Diagnostic Laboratory at Pennsylvania State University; and Dr. Suryaprakash Sambhara, Immunology Laboratory team lead at the Influenza Division of the Centers for Disease Control and Prevention.

Dr. Mittal emphasized that it will be critical to have several vaccine approaches in order to meet global demand for the COVID-19 vaccine. He said at present, there are at least three adenovirus-based COVID-19 vaccines in Phase 3 clinical trials. More than 160 COVID-19 vaccines are at various stages of development. And, December 14, 2020, is a landmark day in the history of coronavirus vaccine efforts in the United States due to the start of the emergency use authorization (EUA) of the Pfizer-BioNTech COVID-19 Vaccine.

Dr. Mittal also cautions that the elderly are the most vulnerable segment of the population because of a higher risk of COVID-19 severity, and therefore, vaccine development efforts should consider the decline in the immune competence of the elderly. The novel vaccine approaches will assist in designing the next generation of COVID-19 vaccine for all population segments.

“An effective COVID-19 vaccine will flatten the COVID-19 pandemic’s trajectory and its second wave, thus saving lives and the global economy,” Dr. Mittal said.


Writer(s): Kevin Doerr | pvmnews@purdue.edu



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