Infectious Diseases and Inflammation 

The immune system of human beings and domestic animals has evolved to protect the body from microbial infections. Vaccination is aimed at mobilizing the immune defense mechanisms and is one of the most successful medical interventions. It has led to the eradication of small pox in people and rinderpest in cattle, and almost complete eradication of polio. Yet, infectious diseases continue to plague human and animal populations. The majority of emerging infectious diseases that affect human beings originate in animals emphasizing the need to control infections in both domestic animals and wildlife populations.

Research in the College of Veterinary Medicine is aimed at the control of infectious diseases that affect humans and animals through improved diagnostics, therapeutics and vaccination. Some of the work includes the development of new diagnostic tests for infectious diseases; development of new antibiotics against Salmonella, Listeria and MRSA; recombinant adenoviral vectors for effective influenza vaccines; the study of influenza and other viral diseases in poultry and swine; and epidemiologic studies of zoonotic infectious diseases.

While the immune system is necessary for the defense against infections, abnormal functioning of the immune system can cause life-threatening and debilitating diseases often associated with chronic inflammation. Such diseases affect both humans and domestic animals, and research in the College of Veterinary Medicine is aimed at the development of novel therapies. Examples of diseases that are being investigated include inflammatory bowel disease, chronic dermatitis, prostatitis, and allergic airway disease in horses.

Faculty

Infectious Diseases:

Diagnostics

• Messick, Joanne (CPB) - hemotropic mycoplasmas
• Pogranichniy, Roman (CPB) – PCR-based assays for viruses
  
• Robinson, J. Paul (BMS) - food safety; spectral imaging
  
• Weng, Hsin-Yi (CPB) - Epidemiology
• Yingst, Samuel (CPB) - molecular diagnostics

Epidemiology

• Moore, George (CPB) - infectious diseases of companion animals

Pathogenesis

• Fairfax, Keke (CPB) - schistosomiasis
• Guptill, Lynn (VCS) - Bartonella henselae
• Kim, Chang (CPB) - innate and adaptive immune responses to infection
• Messick, Joanne (CPB) - hemotropic mycoplasmas
  
• Pogranichniy, Roman (CPB) - Porcine circovirus-associated disease and other viral diseases

Therapeutics

• Seleem, Mohammed (CPB) – novel antibiotics against intracellular bacterial pathogens
• Stiles, Jean (VCS) – infectious diseases of the eye
  
• Townsend, Wendy (VCS) – infectious diseases of the eye
  

Vaccines

• HogenEsch, Harm (CPB) – adjuvants
• Lin, Tsang Long (CPB) – viral diseases of poultry
  
• Mittal, Suresh (CPB) – recombinant adenovirus vectors; pandemic influenza
  
• Pogranichniy, Roman (CPB) – viral diseases of swine; novel delivery systems
  
• Vemulapalli, Ramesh (CPB) – vaccine against brucellosis; Brucella as vaccine vector
  

Inflammation:

• Couetil, Laurent (VCS) – inflammatory airway disease in horses
• Crist, Scott (CPB) – role of platelets in inflammation
  
• Elzey, Ben (CPB) – role of platelets in inflammation
  
• Guptill, Lynn (VCS) – periodontal disease in dogs
  
• HogenEsch, Harm (CPB) – pathogenesis of chronic inflammation
  
• Jones, Yava (CPB) – microbiome and inflammatory bowel disease
  
• Kim, Chang (CPB) – lymphocyte differentiation and trafficking in regulation of immunity and inflammation
  
• Ratliff, Tim (CPB) - prostatitis and prostate cancer
  
• Taylor, Sandy (VCS) – septicemia in foals