Cancer
Cancer refers to a group of diseases caused by uncontrolled proliferation of cells. It is common in dogs, cats and horses, and the study of “spontaneous” cancer in pets contributes to our understanding and improved therapy of cancer in humans. Conversely, advances in cancer therapy in human medicine are used to provide more effective treatments for pets. Causes of cancer vary, but include both genetic and environmental factors. The predisposition of certain breeds of dogs to particular types of cancer is strong evidence for the genetic underpinning of cancer. The Evan and Sue Ann Werling Comparative Oncology Research Center (WCORC) conducts clinical trials in pets aimed at improving the therapeutic outcome of cancer. Through sophisticated genetic engineering, models of cancer can also be induced in laboratory mice and zebra fish, and provide insights into the molecular pathways and genetic basis of cancer.
Research in the College of Veterinary Medicine focuses on several forms of cancer, with a special emphasis on urinary bladder cancer, prostate cancer, breast cancer, lymphoma, nasal tumors and brain tumors. The research ranges from fundamental investigations at the molecular and cellular level to clinical trials.
Faculty
Bioinformatics
- Lanman, Nadia Atallah (CPB)
Brain tumors
- Bentley, Tim (VCS) – surgery, chemotherapy, neuroradiology
- Mendrysa, Susan (BMS) – molecular biology of medulloblastoma
Breast cancer
- Lelièvre, Sophie (BMS) – molecular biology; nutrition and prevention
- Mohammed, Sulma (CPB) – early detection; biomarkers; breast cancer in Africa
Lymphoma
- Childress, Michael (VCS) – therapy
Molecular Biology and Genetics
- Andrisani, Ourania (BMS) – molecular pathogenesis of liver cancer
- Lelièvre, Sophie (BMS) – nuclear architecture and gene expression; epigenetics
- Mendrysa, Susan (BMS) – p53 signaling pathway
- Zhang, Guangjun (CPB) – comparative genomics in zebra fish
Prostate cancer
- Ratliff, Tim (CPB) – role of inflammation; diagnostic biomarkers
Pathology
- Ramos-Vara, Jose (CPB) – immunohistochemistry of tumors in domestic animals
Radiation Oncology
- Isabelle Vanhasesebrouck (VCS)
Urinary bladder cancer
- Knapp, Deborah (VCS) – genetic and environmental risk factors; therapy in dogs
- Santos, Andrea (CPB) - biomarkers
Additional Links
Purdue Institute of Inflammation, Immunology, and Infectious Disease
Purdue Institute for Integrative Neuroscience
Contact Information:
Purdue University College of Veterinary MedicineOffice of Research
625 Harrison Street
West Lafayette, IN 47907
Phone: (765) 496-3487
Email: vetresearch@purdue.edu
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