GuangJun Zhang, Ph.D.

Department of Comparative Pathobiology

John T. and Winifred M. Hayward Assistant Professor of Genetic Research, Genetic Epidemiology and Comparative Medicine

Purdue University College of Veterinary Medicine
625 Harrison Street
West Lafayette, IN 47907

Phone: 765.496.1523
Email: gjzhang@purdue.edu

Zhang Research Group

Education

2007 - PhD | University of Florida
2001 - MS | Chinese Academy of Preventive Medicine, Chinese Center for Disease Control and Prevention
1998 - MD | Tongji University, College of Medicine

Selected Publications

– Hensley, M. R., Chua, R. F., Leung, Y. F., Yang, J. Y., Zhang, G. (2016) Molecular Evolution of MDM1, a "Duplication-Resistant" Gene in Vertebrates. PLoS One 11, e0163229, doi:10.1371/journal.pone.0163229.

– Hensley, M.R., Cui, Z., Chua, R.F.M., Simpson, S., Shammas, N.L., Yang, J.-Y., Leung, Y.F., and Zhang, G. (2016). Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Scientific Reports 6, 27816.

– Tarazona, O.A., Slota, L.A., Lopez, D.H., Zhang, G. & Cohn, M.J. (2016) The genetic program for cartilage development has deep homology within Bilateria. Nature, 533: 86–89.

– Zhang G., Hoersch S., Amsterdam A., Whittaker C.A., Beert E., Catchen, J.M., Farrington, S., Postlethwait, J.H., Legius E., Hopkins, N., Lees, J.A. (2013) Comparative Oncogenomic Analysis of Copy Number Alterations in Human and Zebrafish Tumors Enables Cancer Driver Discovery. PLoS Genetics 9(8): e1003734. doi:10.1371/journal.pgen.1003734

– Zhang G., Vemulapalli, T.H., Yang J.Y. (2013) Phylooncogenomics: Examining the cancer genome in the context of vertebrate evolution. Applied & Translational Genomics, 2: 48-54.

– Zhang G., Hoersch S., Amsterdam A., Whittaker C.A,. Lees J.A., Hopkins N. (2010). Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers. Proceedings of the National Academy of Sciences, 107: 16940-16945.

– Zhang, G. (2009). An Evo-Devo view on the origin of the backbone: evolutionary development of the vertebrae. Integrative and Comparative Biology 49: 178-186.

– Zhang, G. Eames, B.F. and Cohn, M.J. (2009). Evolution of Vertebrate Cartilage Development. Current Topics in Developmental Biology 86: 15-42.

– Zhang, G. and Cohn, M.J. (2008). Genome duplication and the origin of the vertebrate skeleton. Current Opinion in Genetics & Development, 18:387-393.

– Freitas, R., Zhang, G. and Cohn, M. J (2007). Multiphasic expression of HoxA and HoxD genes during shark fin development: implications for the origin of tetrapod limbs. PLoS ONE, 2: e754.

– Zhang, G. and Cohn, M.J. (2006). Hagfish and lancelet fibrillar collagens reveal that type II collagen-based cartilage evolved in stem vertebrates. Proceedings of the National Academy of Sciences, 103: 16829-33.

– Freitas, R., Zhang, G., Cohn, M.J. (2006). Evidence that mechanisms of fin development evolved in the midline of early vertebrates. Nature. 2006 442: 1033-7.

– Zhang, G., Miyamoto, M.M., Cohn, M.J. (2006). Lamprey type II collagen and Sox9 reveal an ancient origin of the vertebrate collagenous skeleton. Proceedings of the National Academy of Sciences, 103: 3180-5.

– Freitas, R., Zhang, G., Albert, J.S., Evans, D.H., Cohn, M.J. (2006). Developmental origin of shark electrosensory organs. Evolution and Development. 8: 74-80.

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