CE Events and Workshops


VCS Seminar: Dr. Zhong-Yin Zhang

“Drugging the Undruggable: Therapeutic Potential of Targeting Protein Tyrosine Phosphatases”

Presenter:  Dr. Zhong-Yin Zhang, Visiting Lecturer

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VCS Seminar: Dr. Silvia Levorato

“Fentanyl Transdermal Delivery System in Dogs and Pigs: Pharmacokinetics Considerations”

Presenter:  Dr. Silvia Levorato, 1st Year Resident, Anesthesiology

Recently interest in veterinary medicine is focused on transdermal drug delivery. The transdermal route appears to be an alternative and advantageous option to reduce stress on animals from multiple injections or from restraint for drug administration. It represents an easy and fast way of administration and could be used for long acting compounds. The bioavailability of most drugs after transdermal delivery is poor and they are unable to reach an effective therapeutic blood concentration. Skin acts as the main obstacle to diffusion and absorption of the medication and the morphology of the stratum corneum seems to be the primary responsible of its low permeability. To promote drug penetration through the skin, these topical products include penetration enhancers, which modify the fluidity of the stratum corneum. The wide variability of skin morphology, biochemical components, blood circulation amounts and distribution among species drives medical research efforts to develop more species specific medications.

In dogs, two transdermal fentanyl delivery solutions have been investigated. One considers the use of patches at different concentrations and the second the use of liquid fentanyl solution in high concentrations (50mg/ml) for pain management. Both the formulations are able to keep a therapeutic plasma fentanyl concentration of 1-2mg/ml, ensuring an adequate level of analgesia. The patches can have an onset time of 24h and a duration of action from 24h to 72h, while the liquid solution seems able to keep the therapeutic fentanyl concentration for almost 96h with an onset time of 2-3h.

Pigs are frequently used as an animal model for humans in surgical procedures. Providing effective analgesia in this specie poses a significant challenge. Repeated injections of parenteral opioids are not practical and continuous opioid infusions are not used because of the lack of easy venous access in pigs. The need for potent and proven long acting analgesia prompted our study to examine a novel use of a liquid transdermal fentanyl solution approved for use in dogs as a long acting analgesic for laboratory pigs.

We examined the PK profile and behavioral side effects of liquid transdermal fentanyl solution in pigs and compared our results with that found in dogs. The PK profile of our study suggests that a single dose of transdermal fentanyl applied on the dorsal interscapular area in pigs is likely to provide post-operative analgesia for at least 96 hours with fewer side effects than that reported in dogs.

One (1) Continuing Education (CE) credit is offered for this seminar.

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2nd Annual CAWS Symposium

This year’s symposium explores current animal welfare challenges and scientific efforts to address these in agricultural, companion and laboratory animal species. The program is intended to be useful for scientists, students, veterinarians, animal producers, animal industry personnel, legislators, and interested members of the general public. 5 Continuing Education (CE) Units are available for this program.

Register for the 2nd Annual Center for Animal Welfare Science Symposium!

View the Preliminary Program (PDF)

Learn more about the Center for Animal Welfare Science at their site, http://vet.purdue.edu/CAWS

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Canine Welfare Science Forum

This inaugural annual forum explores current canine health and welfare challenges.  The ways in which scientific concepts and research results can be practically applied to improve canine welfare in various settings are explored. The program is intended to be useful for animal caretakers and other companion animal industry personnel, scientists, students, veterinarians, legislators, and interested members of the general public. 5 Continuing Education (CE) Units are available for this program.

Sponsored by:

Click here to read the Program

Register for the Canine Welfare Science Forum.

Learn more about the Center for Animal Welfare Science at their site, http://vet.purdue.edu/CAWS

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Bone Marrow Workshop

This workshop is designed for professionals to review normal and pathologic bone marrow in companion animals via cytology and histology. Blood and bone marrow data from case examples will demonstrate correlation between the different biopsy methods. Learn through group discussions and personalized microscopy. Individual microscopes will be provided or bring your own. Trainees will gain confidence in evaluating bone marrow samples. Thirteen (13) Continuing Education (CE) units are available for this program. 

Click here to read the Preliminary Program

Register for the Bone Marrow Workshop

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