Soldiers, athletes could have improved outcomes from traumatic brain injury through faster diagnosis using urine analysis - Sep 4, 2019
A traumatic brain injury is often easily suspected and can be confirmed and treated if necessary following an injury using a blood analysis, but scientists are reporting that even one mild blast to the brain can cause very subtle but permanent damage as well. Urine analysis taken within one week of a mild to traumatic brain injury also can provide faster diagnosis and treatment for such injuries.
Possible new treatment for spinal cord injuries identified in animal studies - Jun 11, 2018
A potential new drug therapy for spinal cord injuries has been identified by researchers at Purdue University. The drug was identified by Riyi Shi, professor in the Department of Basic Medical Sciences, College of Veterinary Medicine and Weldon School of Biomedical Engineering. The drug works in a similar way as a drug previously developed at Purdue, 4-aminopyridine, which has been approved by the U.S. Food and Drug Administration to treat multiple sclerosis.
‘Key factor’ in development of Parkinson’s disease identified - Apr 19, 2018
A molecule has been identified that appears to play an important role in the development of Parkinson’s disease, a debilitating disease that affects millions of people around the world. The discovery could lead to therapies, potentially including drugs currently on the market, and it could facilitate earlier diagnosis and prevention of the neurological disorder.
Neurotoxin in cigarette smoke worsens pain in spinal cord injuries - Jun 14, 2017
Researchers have identified a key component in cigarette smoke that worsens pain in people with spinal cord injury, suggesting that a critical element within tobacco is responsible for such pain-inducing effects.
An old drug with new potential: WWII chemical-weapon antidote shows early promise as treatment for spinal cord injuries - Mar 28, 2017
A drug developed during World War II as an antidote for a chemical warfare agent has been found to be effective at suppressing a neurotoxin that worsens the pain and severity of spinal cord injuries, suggesting a new tool to treat the injuries.
Research suggests diagnostic approach for veterans suffering hearing impairment and related brain injury from mild blast trauma - Mar 16, 2017
A drug developed during World War II as an antidote for a chemical warfare agent has been found to be effective at suppressing a neurotoxin that worsens the pain and severity of spinal cord injuries, suggesting a new tool to treat the injuries.
Glen Acosta receives Eli Lilly and Stark Neurosciences Research Institute Fellowship in Neurodegeneration - Jan 13, 2017
Glen, a student in the Shi Lab, was awarded a pre-doctoral fellowship for his proposal “Critical Intervention Target to Reduce Parkinson’s Disease Susceptibility in Rat Post-Traumatic Brain Injury”.
Study points to potential monitoring approach for personalized treatment of spinal cord injuries - Dec 7, 2016
Researchers have developed a urine test revealing the presence of a neurotoxin that likely worsens the severity and pain of spinal cord injuries, suggesting a new tool to treat the injuries.
New 'lipidomics' method could bring fast cancer diagnosis - Feb 22, 2016
Researchers have developed a new analytical tool for medical applications and biological research that might be used to diagnose cancer more rapidly than conventional methods.
Purdue startup receives funding to accelerate innovation to treat MS pain - Feb 2, 2016
The Elevate Purdue Foundry Fund has awarded Neuro Vigor a $20,000 "Black Award" to accelerate commercialization of its drug therapy for pain in multiple sclerosis.
New pain mechanisms revealed for neurotoxin in spinal cord injury - Nov 23, 2015
A toxin released by the body in response to spinal cord injuries increases pain by causing a proliferation of channels containing pain sensors, new research shows, and this hypersensitivity also extends to peripheral nerves in the limbs far from the injury site.
Wireless sensor enables study of traumatic brain injury - Nov 20, 2015
A new system that uses a wireless implant has been shown to record for the first time how brain tissue deforms when subjected to the kind of shock that causes blast-induced trauma commonly seen in combat veterans.
Laboratory research mimics blast-induced brain trauma in soldiers - Aug 28, 2015
Researchers have developed a procedure to mimic in laboratory experiments a form of brain trauma commonly seen in combat veterans, and findings suggest a new diagnostic tool for early detection and a potential treatment.
TOXIN FROM TOBACCO SMOKE COULD INCREASE PAIN IN SPINAL CORD INJURY AND WORSEN MULTIPLE SCLEROSIS - Dec 3, 2014
A neurotoxin called acrolein found in tobacco smoke that is thought to increase pain in people with spinal cord injury has now been shown to accumulate in mice exposed to the equivalent of 12 cigarettes daily over a short time period.
PURDUE STARTUP COMMERCIALIZING INNOVATION TO REDUCE NEUROTOXIN THAT DAMAGES NERVE CELLS, TRIGGERS PAIN - Sep 26, 2014
A Purdue startup is commercializing a technology that could reduce the symptoms and pain of neurological disease and injury, including multiple sclerosis, neuropathic pain and Parkinson's disease.
NEURO VIGOR LICENSES INNOVATIVE PURDUE TECHNOLOGY TO TREAT NEUROLOGICAL DISEASES - Apr 24, 2014
Neuro Vigor LLC announced Thursday (April 24) the signing of an exclusive worldwide license with Purdue Research Foundation to develop and commercialize technology that promises an innovative approach to reducing the symptoms and pain of neurological disease and injury, including multiple sclerosis, neuropathic pain and Parkinson's disease.
DRUG MAY REDUCE CHRONIC PAIN FOR SPINAL CORD INJURIES - Oct 29, 2013
Researchers have discovered that a known neurotoxin may cause chronic pain in people who suffer from paralysis, and a drug that has been shown to remove the toxin might be used to treat the pain.
TESTING PROMISING FOR SPINAL CORD INJURIES, MULTIPLE SCLEROSIS - Jun 13, 2013
A medical test previously developed to measure a toxin found in tobacco smokers has been adapted to measure the same toxin in people suffering from spinal cord injuries and multiple sclerosis, offering a potential tool to reduce symptoms.
STUDY GETS MAJOR BOOST TO PROBE TOXIN'S ROLE IN SPINAL INJURY, POTENTIAL TREATMENT - Feb 14, 2012
Researchers, led by Dr. Riyi Shi, have received $1.5 million to study the role of a toxin thought to worsen the severity of spinal cord injuries and to learn whether reducing its concentration in the days following trauma also decreases damage that can lead to paralysis.
PURDUE RESEARCH FOUNDATION RECEPTION TO HONOR UNIVERSITY ENTREPRENEURS, RESEARCHERS - November 1, 2011
Fifty-nine Purdue University faculty, staff and students whose discoveries received patents during the 2010-2011 fiscal year will be recognized Wednesday (Nov. 2) during the Purdue Research Foundation's annual Inventors Recognition Reception.
PURDUE RESEARCH MAY LEAD TO THERAPY THAT DELAYS ONSET, REDUCES SEVERITY OF MS SYMPTOMS - March 14, 2011
Purdue professor Riyi Shi conducts research at his laboratory on how hydralazine affects multiple sclerosis symptoms. A provisional patent has...
PURDUE RESEARCH FOUNDATION RECOGNIZES UNIVERSITY RESEARCHERS, ENTREPRENEURS - November 4, 2010
Riyi Shi, professor, Weldon School of Biomedical Engineering, College of Engineering; professor, Department of Basic Medical Sciences, ...
DRUG STUDIED AS POSSIBLE TREATMENT FOR SPINAL INJURIES - November 8, 2009
The collaboration included Borgens; Riyi Shi, an associate professor of biomedical engineering and basic medical sciences; and Kinam Park, ...
SPUN-SUGAR FIBERS SPAWN SWEET TECHNIQUE FOR NERVE REPAIR - February 26, 2009
Riyi Shi, Weldon School of Biomedical Engineering ... in nerves, said Riyi Shi, an associate professor in Purdue's Weldon School of Biomedical...
'CARS' IMAGING REVEALS CLUES TO MYELIN DAMAGE - June 27, 2007
Researchers have discovered that calcium ions could play a crucial role in multiple sclerosis by activating enzymes that degrade the fatty sheath that insulates nerve fibers.
