Brain Tumor Research
The goal of these efforts is to develop treatments that will benefit veterinary patients, and also provide potential translation to human patients. Dr. Bentley's research focuses on all aspects of brain tumors, including diagnosis by MRI, treatment by surgery and non-surgical therapies, and biomarkers such as a blood test to assess tumor burden before and during therapy.
Dr. Bentley is investigating the mechanisms for why canine brain tumors develop and how they can be better treated. This investigation is part of the project “Canine Glioma Cancer Stems Cells as a New Translational Cancer Model.” Biopsy samples from brain tumors are being banked for analysis of an array of biomarkers that may indicate why brain tumors develop and their biological behavior.
Dr. Bentley’s research is also developing and investigating whether a blood test may be able to determine whether a brain abnormality is a tumor, and how large a brain tumor is without having to perform an MRI under anesthesia. This investigation is part of the project “Circulating Progenitor Cells as an Emerging Biomarker in a Canine Model of Solid Tumors.“
Spinal Cord Injury Research
Together with Purdue’s Center for Paralysis Research, the neurology service is investigating the effects of acrolein, which is a byproduct of spinal cord injury. Acrolein plays a role in further damage to the spinal cord after injury, and may be a target for treatment to improve outcome for patients with spinal cord injury.
Ongoing Clinical Trials
Clinical trials are used to determine the safety and/or effectiveness of the new healthcare options. A clinical trial is research which tries to answer specific questions about drugs or new therapies in patients. Carefully conducted clinical trials are the fastest and safest way to investigate new ideas and find treatments that work. Learn more>>
Review current clinical trial recruitment opportunities at the Purdue University College of Veterinary Medicine.