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1/31/2025: 2025 Goodman Campbell Seminar for Neurotrauma and Diseases
The Center for Paralysis Research is thrilled to announce that as of January 2025, our Seminar for Neurotrauma and Diseases will be sponsored by Goodman Campbell Brain and Spine! Goodman Campbell is a world-class neurosurgical institution where leading experts pursue a unique patient-first approach to brain, spine, and nerve care, and CPR is delighted and honored to have them on board for our seminar series. We look forward to deepening our connections with the broader neuroscience community through Goodman Campbell's sponsorship, and are deeply grateful for their support! See here for information about the Spring 2025 seminar series.
12/16/2024: Graduation!
Martina Dalolio graduated at the end of 2024 with her Master's Degree. Congratulations, Martina!
3/29/2024: Scholars in the Spotlight: Keynote Presentation by Dr. Riyi Shi
CPR Director Dr. Riyi Shi will be presenting the keynote "Tracing the Link between Concussion and Alzheimer's Disease: Miniature Brains for Big Problems" for the Center on Aging and the Life Course (CALC) Scholars in the Spotlight event on March 29, 2024 in STEW 279 and via Zoom. If you're interested in attending, please click here to RSVP by March 15!
1/24/2024: Spring 2024 Seminar for Neurotrauma and Diseases
The Spring 2024 Seminar for Neurotrauma and Diseases, sponsored by Plexon, will be returning on February 7th in DLR 131 at 4pm for a mostly in-person semester! Check out our Seminars page for more details; speaker names, talk titles, and locations will be announced shortly as soon as all of the information is finalized. We look forward to seeing you all soon!
Sun, S., Tian, R., Alford, A., Yin, D., Riyi Shi. An analog of phenelzine demonstrates effective acrolein scavenging and neuroprotection without monoamine oxidase inhibition in a rat SCI model. Neuroscience 574: 54-64. https://doi.org/10.1016/j.neuroscience.2025.04.005 2025
Deng, L., Luo, Q., Liu, Y., Wang, Y., Xiong, Z., Wang, H., Zhao, L., Jia, L., Shi, R., Huang, C., Chen, Z. Progressive iron overload in middle-aged mice impairs olfactory function, triggers lipid oxidation and induces apoptosis. Frontiers in Pharmacology 15, https://doi.org/10.3389/fphar.2024.1506944 2024
Zhang, Z., Xiao, T., Hall, M.R., Crodian, J.S., Alford, A., Kimbrough, A., Shi, R. Temporal differential effects of post-injury alcohol consumption in a mouse model of blast-induced traumatic brain injury. Neuroscience 562: 239-251, https://doi.org/10.1016/j.neuroscience.2024.10.003 2024
Beauclair, T., Rogers, E.A., Martinez, J., Mufti, S.J., Krishnan, N., Shi, R. Diffusive secondary injuries in neuronal networks following a blast impact: A morphological and electrophysiological study using a TBI-on-a-Chip model. Brain Multiphysics 7: 100104, https://doi.org/10.1016/j.brain.2024.100104 2024
Herr, S., Prall, A., Shi, R. A perspective on recent findings and future strategies for reactive aldehyde removal in spinal cord injury. Neural Regen Res. doi: 10.4103/1673-5374.369107 2023
Xie, J., Herr, S., Ma, D., Wu, S., Zhao, H., Sun, S., Ma, Z., Chan, M., Li, K., Yang, Y., Huang, F., Shi, R., Yuan, C. Acute transcriptomic and epigenetic alterations at T12 after rat T10 spinal cord contusive injury. Molecular Neurobiology. doi: 10.1007/s12035-023-03250-w 2023
Xia, Y., Luo, Q., Huang, C., Shi, L., Jahangir, A., Pan, T., Wei, X., He, J., Liu, W., Shi, R., Geng, Y., Fang, J., Tang, L., Guo, H., Ouyang, P., Chen, Z. Ferric citrate-induced colonic mucosal damage associated with oxidative stress, inflammation responses, apoptosis, and the changes of gut microbial composition. Ecotoxicology and Environmental Safety 249:114364. doi: 10.11016/j.ecoenv.2022.114364. 2023
Suresh, S., Everett, T.H., Shi, R., Duerstock, B. Automatic detection and characterization of autonomic dysreflexia using multi-modal non-invasiv sensing and neural networks. Neurotrauma Reports 3(1):501-510. doi: 10.1089/neur.2022.0041. 2022.
Rogers, E. A., Beauclair, T., Thyen, A., Shi, R. Utilizing novel TBI-on-a-chip device to link physical impacts to neurodegeneration and decipher primary and secondary injury mechanisms. Sci Rep 12(1):11838. doi: 10.1038/s41598-022-14937-w. 2022
Herr, S., Gardeen, S., Low, P., Shi, R. Targeted delivery of acrolein scavenger hydralazine in spinal cord injury using folate-linker-drug conjugation. Free Radical Biology and Medicine. doi: 10.1016/j.freeradbiomed.2022.04.003. 2022
Herr, S.A., Shi, L., Gianaris, T., Jiao, Y., Sun, S., Race, N., Shapiro, S., Shi, R. Critical role of mitochondrial aldehyde dehydrogenase 2 in acrolein sequestering in rat spinal cord injury. Neural Regen Res. 17(7):1505-1511. doi: 10.4103/1673-5374.330613. 2022.
Shen, X., Ozen, A.C., Sunjar, A. Ilbey, S., Shi, R., Chiew, M., Emir, U. Myelin imaging using 3D dual-echo ultra-short echo time MRI with rosette k-space pattern. doi: 10.1101/2021.09.18.460869 2022.
Han, E., Fernandez, J., Swanberg, C., Shi, R., Bartlett, E. Longitudinal auditory pathophysiology following mild blast-induced trauma. J Neurophysiol. 126:1172-1189. 2021.
Herr, S., Malek, S., Rochat, M. C., Moore, G. E., Ko, J. C., Shi, R. Evidence of acrolein in synovial fluid of dogs with osteoarthritis as a potential inflammatory biomarker. BioMed Central. doi: 10.1186/s12891-021-04762-z 2021.
Han, H. X., Fernandez, J. M., Swanberg, C., Shi, R., Bartlett, E. Longitudinal auditory pathophysiology following mild blast induced trauma. BioRxiv. DOI: doi: 10.1101/2020.11.06.371591. 2021.
De Rus Jacquet, A., Ambaw, A., Tambe, M., Ma, S., Timmers, M., Grace, M., Wu, Q., Simon, J., McGabe, G., Lila, M., Shi, R., Rochet, J. Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models. Food and Function. doi: 10.1039/D1FO00007A. 2021.
Eaton, M., Que, Z., Zhang, J., Beck, K., Shi, R., McDermott, J., Ladisch, M., Yang, Y. Multi-electrode array of sensory neurons as an in vitro platform to identify the nociceptive response to pharmaceutical buffer systems of injectable biologics. Pharmaceutical Research. doi: 1007/s11095-021-03075-z 2021.
Race, N. S., Andrews, K. D., Lungwitz, E. A., Vega Alvarez, S. M., Warner, T. R., Acosta, G., Cao, J., Lu, K., Liu, Z., Dietrich, A. D., Majumdar, S., Shekar, A., Truitt, W. A., Shi, R. Psychosocial impairment following mild blast-induced traumatic brain injury in rats. Behavioral Brain Research. doi: 10.1016/j.bbr.2021.113405 2021.
Shi, L., Lin, Y., Jiao, Y., Herr, S., Tang, J., Rogers, E., Chen, Z., Shi, R. Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson's disease: Implication of acrolein and TRPA1. Translational Neurodegeneration, 10(13). doi: 10.1186/s40035-021-00239-0 2021.
Kish, B., Herr, S., Yang, H., Sun, S., Shi, R., Tong, Y. Whole body measurements using near-infrared spectroscopy in a rat spinal cord contusion injury model. The Journal of Spinal Cord Medicine. doi: 1080/10790268.2021.1911504 2021.
Uzunalli, G., Herr, S., Dieterly, A. M., Shi, R., Lyle, L. T. Structural disruption of the blood-brain barrier in repetitive primary blast injury. BioMed Central, 18(2). doi: 10.1186/s12987-020-00231-2 2021.
Ren, Z., Qi, Y., Sun, S., Tao, Y., Shi, R. Mesenchymal stem cell-derived exosomes: Hope for spinal cord injury repair. Stem Cells and Development, 29(23). doi: 10.1089/scd.2020.0133 2020.
Nguyen, T. N. H., Nolan, J. K., Cheng, X., Park, H., Wang, Y., Lam, S., Lee, H., Kim, S. J., Shi, R., Chubykin, A. A., Lee, H. Fabrication and ex vivo evaluation of activated carbon-Pt microparticle based glutamate biosensor. Journal of Electoanalytical Chemistry, 866. doi: 10.1016/j.jelechem.2020.114136 2020.
Shi, L., Huang, C., Luo, Q., Xia, Y., Liu, W., Zeng, W., Cheng, A., Shi, R., Zhengli, C. Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway. Aging, 12(10), 9515-9533. doi: 10.18632/aging.103225 2020.
Latorre, A., Kwong, M. T., Garcie-Grajales, J. A., Shi, R., Jerusalem, A., Peña, J. Model calibration using a parallel differential evolution algorithm in computational neuroscience: Simulation of stretch induced nerve deficit. Journal of Computational Science, 39. doi: 10.1016/j.jocs.2019.101053 2019.
Chong, L., Tian, R., Shi, R., Ouyang, Z., Xia, Y. Coupling the Paternò-Büchi (PB) reaction with mass spectrometry to study unsaturated fatty acids in mouse model of multiple sclerosis. Frontiers in Chemistry, 7(807). doi: 10.3389/fchem.2019.00807 2019.
Huang, C., Ma, W., Luo, Q., Shi, L., Xia, Y., Lao, C., Liu, W., Zou, Y., Cheng, A., Shi, R., Chen, Z. Iron overload resulting from the chronic oral administration of ferric citrate induces parkinsonism phenotypes in middle-aged mice. Aging, 11(21), 9846-9861. doi: 10.18632/aging.102433 2019.
Nolan, J. K., Nguyen, T. N. H., Fattah, M., Page, J. C., Shi, R., Lee, H. Ex vivo electrochemical measurement of glutamate release during spinal cord injury. MethodsX, 6, 1894-1900. doi: 10.1016/j.mex.2019.08.008 2019.
Shi, L., Huang, C., Luo, Q., Rogers, E., Xia, Y., Liu, W., Ma, W., Zeng, W., Gong, L., Fang, J., Tang, L., Cheng, A., Shi, R., Chen, Z. The association of iron and the pathologies of Parkinson’s Diseases in MPTP/MPP +- induced neuronal degeneration in non-human primates and in cell culture. Frontiers in Aging Neuroscience, 11(215). doi: 10.3389/fnagi.2019.00215 2019.
Vike, N., Tang, J., Talavage, T., Shi, R., Rispoli, J. Determination of acrolein-associated T1 and T2 relaxation times and noninvasive detection using nuclear magnetic resonance and magnetic resonance spectroscopy. Applied Magnetic Resonance, 50(11), 1291-1303. doi: 1007/s00723-019-01148-2 2019.
Acosta, G., Race, N., Herr, S., Fernandez, J., Tang, J., Rogers, E., Shi, R. Acrolein-mediated alpha-synuclein pathology involvement in the early post-injury pathogenesis of mild blast-induced Parkinsonian neurodegeneration. Molecular and Cellular Neuroscience, 98, 140-154. doi: 1016/j.mcn.2019.06.004 2019.
Nguyen, T. N. H., Nolan, J. K., Park, H., Lam, S., Fattah, M., Page, J. C., Joe, H., Jun, M. B. G., Lee, H., Kim, S. J., Shi, R., Lee, H. Facile fabrication of flexible glutamate biosensor using direct writing of platinum nanoparticle-based nanocomposite ink. Biosensors and Bioelectronics, 131,257-266. doi: 10.1016/j.bios.2019.01.051 2019.
Li, J. Weak direct current (DC) electric fields as a therapy for spinal cord injuries: Review and advancement of the oscillating field stimulator (OFS). Neurosurgical Review, 42, 825-834. doi: 1007/s10143-018-01068-y 2019.
