News & Publications

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3/29/2024:  Scholars in the Spotlight: Keynote Presentation by Dr. Riyi Shi

CPR Director Dr. Riyi Shi will be presenting the keynote "Tracing the Link between Concussion and Alzheimer's Disease: Miniature Brains for Big Problems" for the Center on Aging and the Life Course (CALC) Scholars in the Spotlight event on March 29, 2024 in STEW 279 and via Zoom. If you're interested in attending, please click here to RSVP by March 15!

1/24/2024:  Spring 2024 Seminar for Neurotrauma and Diseases

The Spring 2024 Seminar for Neurotrauma and Diseases, sponsored by Plexon, will be returning on February 7th in DLR 131 at 4pm for a mostly in-person semester! Check out our Seminars page for more details; speaker names, talk titles, and locations will be announced shortly as soon as all of the information is finalized. We look forward to seeing you all soon!

9/6/2023: Fall 2023 Seminar for Neurotrauma and Diseases

The Fall 2023 Seminar for Neurotrauma and Diseases, sponsored by Plexon, will be returning on September 6th at 4pm in DLR 131! This semester will be entirely in-person, but we'll be maintaining our hybrid option for those who can't attend in-person. Check out our Seminars page for more details, including speaker names, talk titles, and the link for the online presentation.

8/29/2023: TBI-on-a-Chip

CPR's "TBI-on-a-chip" study was featured in a Purdue University press release accompanying the publication of our paper "The contribution of initial concussive forces and resulting acrolein surge to β-amyloid accumulation and functional alterations in neuronal networks using a TBI-on-a-chip model" in Lab on a Chip this August. The TBI-on-a-chip device allows researchers to track the effects of specific concussive forces on clusters of cultured neuronal cells, making it possible to study the damage done by a concussion immediately after injury.

Check out the press release here!







Herr, S., Prall, A., Shi, R. A perspective on recent findings and future strategies for reactive aldehyde removal in spinal cord injury. Neural Regen Res. doi: 10.4103/1673-5374.369107 2023

Xie, J., Herr, S., Ma, D., Wu, S.,  Zhao, H., Sun, S., Ma, Z., Chan, M., Li, K., Yang, Y., Huang, F., Shi, R., Yuan, C. Acute transcriptomic and epigenetic alterations at T12 after rat T10 spinal cord contusive injury. Molecular Neurobiology. doi: 10.1007/s12035-023-03250-w 2023

Xia, Y., Luo, Q., Huang, C., Shi, L., Jahangir, A., Pan, T., Wei, X., He, J., Liu, W., Shi, R., Geng, Y., Fang, J., Tang, L., Guo, H., Ouyang, P., Chen, Z. Ferric citrate-induced colonic mucosal damage associated with oxidative stress, inflammation responses, apoptosis, and the changes of gut microbial composition. Ecotoxicology and Environmental Safety 249:114364. doi: 10.11016/j.ecoenv.2022.114364. 2023

Suresh, S., Everett, T.H., Shi, R., Duerstock, B. Automatic detection and characterization of autonomic dysreflexia using multi-modal non-invasiv sensing and neural networks. Neurotrauma Reports 3(1):501-510. doi: 10.1089/neur.2022.0041. 2022.

Rogers, E. A., Beauclair, T., Thyen, A., Shi, R. Utilizing novel TBI-on-a-chip device to link physical impacts to neurodegeneration and decipher primary and secondary injury mechanisms. Sci Rep 12(1):11838. doi: 10.1038/s41598-022-14937-w. 2022



Herr, S., Gardeen, S., Low, P., Shi, R. Targeted delivery of acrolein scavenger hydralazine in spinal cord injury using folate-linker-drug conjugation. Free Radical Biology and Medicine. doi: 10.1016/j.freeradbiomed.2022.04.003. 2022

Herr, S.A., Shi, L., Gianaris, T., Jiao, Y., Sun, S., Race, N., Shapiro, S., Shi, R. Critical role of mitochondrial aldehyde dehydrogenase 2 in acrolein sequestering in rat spinal cord injury. Neural Regen Res. 17(7):1505-1511. doi: 10.4103/1673-5374.330613. 2022.

Shen, X., Ozen, A.C., Sunjar, A. Ilbey, S., Shi, R., Chiew, M., Emir, U. Myelin imaging using 3D dual-echo ultra-short echo time MRI with rosette k-space pattern. doi: 10.1101/2021.09.18.460869  2022.

Han, E., Fernandez, J., Swanberg, C., Shi, R., Bartlett, E. Longitudinal auditory pathophysiology following mild blast-induced trauma.  J Neurophysiol. 126:1172-1189. 2021.

Herr, S., Malek, S., Rochat, M. C., Moore, G. E., Ko, J. C., Shi, R. Evidence of acrolein in synovial fluid of dogs with osteoarthritis as a potential inflammatory biomarker. BioMed Central. doi: 10.1186/s12891-021-04762-z 2021.

Han, H. X., Fernandez, J. M., Swanberg, C., Shi, R., Bartlett, E. Longitudinal auditory pathophysiology following mild blast induced trauma. BioRxiv. DOI: doi: 10.1101/2020.11.06.371591. 2021.

De Rus Jacquet, A., Ambaw, A., Tambe, M., Ma, S., Timmers, M., Grace, M., Wu, Q., Simon, J., McGabe, G., Lila, M., Shi, R., Rochet, J. Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models. Food and Function. doi: 10.1039/D1FO00007A. 2021.

Eaton, M., Que, Z., Zhang, J., Beck, K., Shi, R., McDermott, J., Ladisch, M., Yang, Y. Multi-electrode array of sensory neurons as an in vitro platform to identify the nociceptive response to pharmaceutical buffer systems of injectable biologics. Pharmaceutical Research. doi: 1007/s11095-021-03075-z 2021.

Race, N. S., Andrews, K. D., Lungwitz, E. A., Vega Alvarez, S. M., Warner, T. R., Acosta, G., Cao, J., Lu, K., Liu, Z., Dietrich, A. D., Majumdar, S., Shekar, A., Truitt, W. A., Shi, R. Psychosocial impairment following mild blast-induced traumatic brain injury in rats. Behavioral Brain Research. doi: 10.1016/j.bbr.2021.113405 2021.



Shi, L., Lin, Y., Jiao, Y., Herr, S., Tang, J., Rogers, E., Chen, Z., Shi, R. Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson's disease: Implication of acrolein and TRPA1. Translational Neurodegeneration, 10(13). doi: 10.1186/s40035-021-00239-0 2021.

Kish, B., Herr, S., Yang, H., Sun, S., Shi, R., Tong, Y. Whole body measurements using near-infrared spectroscopy in a rat spinal cord contusion injury model. The Journal of Spinal Cord Medicine. doi: 1080/10790268.2021.1911504 2021.

Uzunalli, G., Herr, S., Dieterly, A. M., Shi, R., Lyle, L. T. Structural disruption of the blood-brain barrier in repetitive primary blast injury. BioMed Central, 18(2). doi: 10.1186/s12987-020-00231-2 2021.

Ren, Z., Qi, Y., Sun, S., Tao, Y., Shi, R. Mesenchymal stem cell-derived exosomes: Hope for spinal cord injury repair. Stem Cells and Development, 29(23). doi: 10.1089/scd.2020.0133 2020.

Nguyen, T. N. H., Nolan, J. K., Cheng, X., Park, H., Wang, Y., Lam, S., Lee, H., Kim, S. J., Shi, R., Chubykin, A. A., Lee, H. Fabrication and ex vivo evaluation of activated carbon-Pt microparticle based glutamate biosensor. Journal of Electoanalytical Chemistry, 866. doi: 10.1016/j.jelechem.2020.114136 2020.



Shi, L., Huang, C., Luo, Q., Xia, Y., Liu, W., Zeng, W., Cheng, A., Shi, R., Zhengli, C. Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway. Aging, 12(10), 9515-9533. doi: 10.18632/aging.103225 2020.

Latorre, A., Kwong, M. T., Garcie-Grajales, J. A., Shi, R., Jerusalem, A., Peña, J. Model calibration using a parallel differential evolution algorithm in computational neuroscience: Simulation of stretch induced nerve deficit. Journal of Computational Science, 39. doi: 10.1016/j.jocs.2019.101053 2019.

Chong, L., Tian, R., Shi, R., Ouyang, Z., Xia, Y. Coupling the Paternò-Büchi (PB) reaction with mass spectrometry to study unsaturated fatty acids in mouse model of multiple sclerosis. Frontiers in Chemistry, 7(807). doi: 10.3389/fchem.2019.00807 2019.

Huang, C., Ma, W., Luo, Q., Shi, L., Xia, Y., Lao, C., Liu, W., Zou, Y., Cheng, A., Shi, R., Chen, Z. Iron overload resulting from the chronic oral administration of ferric citrate induces parkinsonism phenotypes in middle-aged mice. Aging, 11(21), 9846-9861. doi: 10.18632/aging.102433 2019.

Nolan, J. K., Nguyen, T. N. H., Fattah, M., Page, J. C., Shi, R., Lee, H. Ex vivo electrochemical measurement of glutamate release during spinal cord injury. MethodsX, 6, 1894-1900. doi: 10.1016/j.mex.2019.08.008 2019.

Shi, L., Huang, C., Luo, Q., Rogers, E., Xia, Y., Liu, W., Ma, W., Zeng, W., Gong, L., Fang, J., Tang, L., Cheng, A., Shi, R., Chen, Z. The association of iron and the pathologies of Parkinson’s Diseases in MPTP/MPP +- induced neuronal degeneration in non-human primates and in cell culture. Frontiers in Aging Neuroscience, 11(215). doi: 10.3389/fnagi.2019.00215 2019.

Vike, N., Tang, J., Talavage, T., Shi, R., Rispoli, J. Determination of acrolein-associated T1 and T2 relaxation times and noninvasive detection using nuclear magnetic resonance and magnetic resonance spectroscopy. Applied Magnetic Resonance, 50(11), 1291-1303. doi: 1007/s00723-019-01148-2 2019.

Acosta, G., Race, N., Herr, S., Fernandez, J., Tang, J., Rogers, E., Shi, R. Acrolein-mediated alpha-synuclein pathology involvement in the early post-injury pathogenesis of mild blast-induced Parkinsonian neurodegeneration. Molecular and Cellular Neuroscience, 98, 140-154. doi: 1016/j.mcn.2019.06.004 2019.

Nguyen, T. N. H., Nolan, J. K., Park, H., Lam, S., Fattah, M., Page, J. C., Joe, H., Jun, M. B. G., Lee, H., Kim, S. J., Shi, R., Lee, H. Facile fabrication of flexible glutamate biosensor using direct writing of platinum nanoparticle-based nanocomposite ink. Biosensors and Bioelectronics, 131,257-266. doi: 10.1016/j.bios.2019.01.051 2019.

Li, J. Weak direct current (DC) electric fields as a therapy for spinal cord injuries: Review and advancement of the oscillating field stimulator (OFS). Neurosurgical Review, 42, 825-834. doi: 1007/s10143-018-01068-y 2019.