Browse our featured faculty and their research. For the full CPB directory click here.
Research Assistant Professor
Research Information:His research goal is to obtain mechanistic view of cellular pathways and processes using systems-level knowledge. Uma has published more than 30 peer reviewed research and review articles. At the Bindley, Dr. Aryal continues working with other researchers at the interface between biology and proteomics, and is interested to develop new MS-based tools to discover new protein complexes, and protein-protein interactions.
Wendy Beauvais, BVetMed, MSc (VetEpi), PhD
Assistant Professor of Epidemiology and Public Health
Research Information:Dr. Wendy Beauvais is a veterinary epidemiologist with methodological strengths in analytic epidemiology (including study design, data collection, data analysis), and exploratory and predictive epidemiology (including mathematical modelling and risk assessment). I am motivated by developing new methodological approaches to global sustainability challenges, particularly: meeting global demands for safe food, controlling zoonotic diseases, combatting antimicrobial resistance, and protecting endangered wildlife. A common theme in my research is dealing with different types of uncertainty, including epistemic uncertainties (lack of knowledge), stochasticity (inherent randomness) and natural variation (often by time and space). I am particularly excited about using simulation tools to synthesize evidence and inform decision-making.
Alan Beck, ScD
DIRECTOR OF THE CENTER FOR THE HUMAN-ANIMAL BOND AND DOROTHY N. MCALLISTER PROFESSOR OF ANIMAL ECOLOGY
Dr. Alan Beck’s research focuses on basic and applied studies on our attachment with nature. Our attraction to nature is so inborn it survives dementia. In collaboration with the School of Nursing they are showing how adding fish tanks into the environment where Alzheimer’s disease patients live had a calming effect and lessened destructive behaviors, increased food uptake. Their studies have been extended to include the effect on the caregivers. He is also studying the epidemiology of serious and fatal dog attacks and the effectiveness of animal control laws. For engagement Dr. Beck serves as the co-editor for the Purdue University Press series New Directions in the Human-Animal Bond.http://www.thepress.purdue.edu/series/new-directions-human-animal-bond
Dr. Beck also serves as the PI for PVM Purdue Libraries collaborative platform hosted on HUBzero, HABRI Central (habricentral.org).
John A. Christian, DVM (Honors), PhD
ASSOCIATE PROFE OF VETERINARY CLINICAL PATHOLOGY, AND LAB DIRECTOR AND SECTION CHIEF, CLINICAL PATHOLOGY
Dr. John Christian’s clinically oriented research involves validation of new instruments and assays used for monitoring health and diagnosing/monitoring disease states in veterinary patients. We ensure equipment and assays meet standards for diagnostic accuracy and precision. The Clinical Pathology Lab’s state of the art instrumentation is maintained with appropriate quality control and quality assurance programs that offer the follow testing categories: hematology, hemostasis, clinical chemistry, urinalysis, endocrine and diagnostic cytology. We can support clinical diagnostic testing and a variety of research projects that use these testing modalities. Accurate test results aid clinicians in clinical decision making. Laboratory support of research studies leads to a wide range of benefits potentially involving many disciplines. Research is directly related to veterinary medicine by testing blood and other body fluids in a wide range of veterinary patients and research projects. Dr. Christian teaches veterinary clinical pathology, which includes sub-disciplines such as hematology, hemostasis, clinical chemistry profiling of major organ systems, and diagnostic cytology. These classes include basic principles of normal physiology of health and mechanisms of diseases (pathology) that disturb health. Teaching is at all levels of the veterinary team including veterinary technology students, DVM students, interns, residents and graduate students.
On a somewhat informal basis, Dr. Christian also provides thoughts, anecdotes and principles of non-technical skills into his formal classes to help mentor students in coping, self-awareness, healthy self-talk, and other facets of emotional intelligence that are critical to success in professional education and practice.
Dr. Christian engages in public speaking at veterinary continuing education seminars and workshops in the same subject areas as described in teaching.
Abigail Cox, DVM, PhD
ASSOCIATE PROFESSOR OF VETERINARY ANATOMIC PATHOLOGY
Research Information:Dr. Abby Cox pursues a unique area of translational research that focuses on understanding the pathophysiology of voice disorders and the gross and microscopic anatomy of the vocal folds across species. Her research explores the intersection of pathology, physiology, histology, and phonation mechanics that affects 7.5 million people with voice problems in the United States. She has published peer-reviewed articles in her laryngopathology research and has presented her research at local and national meetings. She maintains ongoing research grant support for her projects dealing with vocal fold pathobiology and biomechanics.
Candace Croney, PhD
ASSOCIATE VICE PROVOST OF DIVERSITY, INCLUSION AND BELONGING AND DIRECTOR OF THE CENTER FOR ANIMAL WELFARE SCIENCE AND PROFESSOR OF ANIMAL BEHAVIOR AND WELL-BEING
Research Information:Dr. Candace Croney's goal is to generate new information about best care practices for agricultural and companion animals. She uses animals' behavioral, cognitive and physical health responses to evaluate their quality of life, focusing on dogs in commercial breeding kennels, confined cats, and farmed pigs. She also studies to understand the ethical implications of animal care and use decisions, and public perceptions of animal agriculture, animal welfare and related policies. The results of her studies are used by educators, farmers, retailers, restaurant chains, pet industry groups, governmental and non-governmental organizations focused on improving animal welfare and public outreach. Her research on canine welfare recently resulted in a new national certification program that sets rigorous standards for the care of dogs and puppies by professional dog breeders.
ASSISTANT PROFESSOR OF VETERINARY PARISITOLOGY
Research Information:Dr. Sriveny Dangoudoubiyam researchs zoonotic ascarids and larva migrans Anthelmintic resistance in parasites host-pathogenic interaction of tissue-cyst producing coccidia.
Amanda Darbyshire, DVM, Diplomate, ACLAM
Laboratory Animal Veterinarian
RESEARCH ASSISTANT PROFESSOR
Dr. Bennett D. Elzey is a Research Assistant Professor in the Department of Comparative Pathobiology. His research interests include investigating and understanding the immunosuppressive role of myeloid-derived suppressor cells that prevents effective immunotherapy of cancers, and the role platelet CD40 Ligand plays in shaping the adaptive immune response. He is also the Director of the Biological Evaluation Shared Resource in the Purdue University Center for Cancer Research where Center members’ novel anti-tumor drugs or therapies can be tested for efficacy in rodent models for most cancer types.
Kenitra Hendrix, DVM, PhD, DACVM
DIRECTOR OF THE INDIANA DISEASE AND DIAGNOSTIC LABORATORY AND CLINICAL ASSOSCIATE PROFESSOR OF VETERINARY DIAGNOSTIC MICROBIOLOGY AND SECTION HEAD OF THE BACTERIOLOGY, MYCOLOGY, PARASITOLOGY AND VIROLOGY LABORATORIES
As director of the ADDL, Dr. Kenitra Hendrix works with clinicians to identify bacterial pathogens causing clinical disease and guides them in using diagnostic evidence to aid in treatment and management decisions. Dr. Hendrix's primary research interests include antimicrobial resistance at the diagnostic laboratory level and improving infection control policies and procedures in veterinary hospitals in order to optimize patient care. She is actively involved as a collaborator on projects designed to have practical impacts such as improving procedures for sampling the environment for contamination by pathogens, enhancing identification methods for pathogens, and refining sterilization methods for surgical equipment used in laboratory animal medicine.
Harm HogenEsch, DVM, PhD
ASSOCIATE DEAN FOR RESEARCH AND PROFESSOR OF IMMUNOPATHOLOGY
Research Information:Dr. Harm HogenEsch’s laboratory is interested in increasing the efficacy and safety of vaccines by developing new adjuvants and improving vaccine formulations. Their work focuses on vaccines to be used in animals and humans. A second line of research in Dr. HogenEsch’s lab is aimed at developing better diagnostic methods and therapies for chronic allergic diseases such as atopic dermatitis.
Stephen B. Hooser, DVM, PhD, DABVT
PROFESSOR OF TOXICOLOGY AND HEAD, TOXICOLOGY SECTION, ADDL; DIPLOMATE, AND PAST PRESIDENT, AMERICAN BOARD OF VETERINARY TOXICOLOGY
Research Information:Dr. Stephen Hooser’s primary appointment is in Engagement as the Head of the Toxicology Section of the Animal Disease Diagnostic Laboratory. In this capacity, he communicates and consults with veterinarians and animal owners regarding suspected or confirmed cases of poisoning in animals. In addition, he helps guide diagnostic testing and provides interpretation of results. Dr. Hooser also speaks to veterinary and lay audiences about toxicoses in animals. Teaching: Dr. Hooser teaches veterinary toxicology to D.V.M. and veterinary technology students. Research: Dr. Hooser’s research interests are in mechanisms of liver injury, hepatotoxicants and development of new diagnostic methods.
Christoph Konradt, PhD
Assistant Professor of Immunology
Research Focus 1: The role of EC in the immune response
There are more than 10 trillion EC in the human body, that cover 4000 m2, and these are an important replicative niche for a subset of micro-organisms such as Dengue virus, West Nile Virus, CMV, S. aureus and T. gondii. For many micro-organisms the ability to infect EC is a key part of their pathogenesis. Indeed, EC express TLR and influence coagulation and neutrophil recruitment and their activation can lead to vascular damage, while expression of adhesion molecules promotes extravasation of inflammatory cells. Numerous in vitro studies have demonstrated that EC can be activated by cytokines to limit viral, bacterial and parasite replication. Furthermore, evidence that EC interact with the adaptive response is implicit in the ability of EC to present MHC class I & II restricted antigens. However, whether EC antigen presentation via MHC-I or MHC-II has a tolerogenic or inflammatory role during infection remains unclear. Therefore, there is a major knowledge gap in our understanding in the involvement of EC in orchestrating a T cell response or how the immune system reacts to infected EC in vivo.
Research Focus 2: Immune responses at the Maternal-Fetal Interface
The maternal-fetal interface is the interface between the uterine mucosa and the extraembryonic tissues of the developing conceptus. The placenta functions as the primary nutrient and gas exchange organ of the fetus by diverting maternal blood flow from the uterus. Once inside the placenta, maternal blood exchanges nutrients, gases, and metabolic waste products with fetal blood coursing through a physically separate vasculature that connects to the fetus via the umbilical cord. A successful pregnancy involves complex interactions between fetal trophoblasts, endothelial cells and maternal decidual immune cells, creating an immunologically unique site that allows the tolerance to the allogenic fetus but still maintains host defense against possible pathogens. Infections are a well-described cause for fetal losses and stillbirths, as well as for perinatal morbidity. Indeed, infections are accounted for up to 15% of early miscarriages and up to 66% of late miscarriages. Moreover, infections can further lead to preterm birth or infants with birth defects leading to lifelong disabilities. This is accompanied with significant health care costs and a burden for the mothers mental health and psychological wellbeing. Immune responses at the maternal-fetal interface during infection are poorly understood and there is a real need for a better understanding of the immunological mechanisms at this site.
Nadia Atallah Lanman, PhD
RESEARCH ASSISTANT PROFESSOR
Research Information:Dr. Nadia Lanman is a Research Assistant Professor of Comparative Pathobiology and the Manager of the Purdue Collaborative Core for Cancer Bioinformatics. Dr. Lanman’s research interests are focused on using bioinformatics to gain insights into cancer biology. Cancer is a highly heterogeneous disease, which complicates identification of proper treatment protocols, of ongogenic drivers, and in alterations which lead to treatment resistance. Using a combination of genotypic, transcriptomic, epigenetic, and phenotypic information can lead to a greater understanding of the drivers of oncogenesis as well as the development of resistance to chemotherapy. Dr. Lanman is paticularly interested in data integration and the use of large-scale datasets to generate predictive models that can inform treatment decisions. An additional research interest is in the development of tools that provide biological insights from high throughput sequencing data, particularly in the field of epigenomics.
Joanne B. Messick, VMD, PhD
PROFESSOR OF VETERINARY CLINICAL PATHOLOGY
Research Information:Dr. Joanne Messick’s lab focuses on hemotropic mycoplasmas (hemoplasmas), blood-borne bacteria that targets red blood cells of many different mammalian species (cats, dogs, pigs, sheep, alpacas, and others). The bacteria may cause a primary infection (acute hemolytic anemia) in cats and sheep, while chronic, often asymptomatic infection in pigs and alpacas is the more common presentation. It’s not clear why these hemoplasmas affect some of the host species differently. Those differences are a driving force behind the genomics research that Dr. Messick and her graduate students are doing on the bacteria. An additional area of research interest in the Messick lab is exploring the development of red blood cell antioxidant defenses in cats with diabetes. The cat’s cells are extremely sensitivity to damage by these radicals, especially their red blood cells. By studying the control of gene expression (microRNAs), they hope to identify the weak point(s) in the of the antioxidant mechanisms in feline red blood cells and target it therapeutically to reverse the red cell and systemic effects of free radicals.
Margaret (Peg) Miller, DVM, PhD
ANATOMIC PATHOLOGY TRAINING COORDINATOR AND PROFESSOR OF VETERINARY PATHOLOGY
Research Information:Dr. Margaret (Peg) Miller is a veterinary pathologist working as a diagnostic pathologist, educator of veterinary students and pathology residents, and collaborative investigator in a variety of projects, many of which are focused on neoplastic disease. She is the course coordinator for veterinary systemic pathology in the DVM curriculum and the spring semester seminar in veterinary pathology for anatomic pathology residents.
Suresh K. Mittal, DVM, PhD
DISTINGUISHED PROFESSOR OF VIROLOGY, UNIVERSITY FACULTY SCHOLAR, MEMBER OF PURDUE CANCER CENTER, AND MEMBER OF BINDLEY BIOSCIENCE CENTER
Research Information:Dr. Suresh Mittal is one of the leaders in designing novel adenoviral vectors for gene delivery. He is working for the development of a universal influenza vaccine taking into consideration of emerging avian influenza viruses. He is also developing strategies for immunotherapy for cancer. Recently he has initiated a collaborative program to develop an effective vaccine for Mycobacterium tuberculosis. Other areas of his expertise include animal models for infectious diseases and cancer, and innate and adaptive immunity.
Sanjeev Narayanan, BVSc, PhD
PROFESSOR AND HEAD OF THE DEPARTMENT OF COMPARATIVE PATHOBIOLOGY
Dr. Sanjeev Narayanan is a board certified Veterinary Pathologist and Veterinary Microbiologist. Dr. Narayanan’s research focuses on identifying tools and practices that reduce the use of antibiotics in food animals. Vaccination and feeding probiotics are two viable alternatives currently tested for their effectiveness in reducing the incidence of multidrug resistant bacteria in animal facilities. This research has tremendous impact on human health because it reduces the rise and spread of antibiotic resistance in our environment. Efforts are on to develop vaccines for important diseases of cattle currently controlled by antibiotic use, such as liver abscesses.
Maggie E. O'Haire, PhD
ASSOCIATE PROFESSOR OF HUMAN-ANIMAL INTERACTION
Her research program focuses on the unique and pervasive ways that humans interact with animals. From research with household pets to highly trained service animals, her findings have been instrumental in evaluating the effects of human-animal interactions. She has received funding from three different NIH institutes (NICHD, NCCIH, NCATS) to fund her human-animal interaction research. Check out an interview with Dr. O’Haire and NIH Medline Plus to see her advice on becoming a human-animal interaction researcher.