Glycogen Storage Disease (GSD) PCR

Specimen

Collection Information

Select the appropriate Sample Collection Protocol based on the sample type that will be submitted.
Cheek Swab
Blood
Semen
Dew Claw and Tail Docking

Shipping Information

A completed submission form and receipt of payment must be included in the package with any samples before any testing will begin.

Please include all samples for a given order IN THE SAME SHIPMENT. If you are unable to submit a sample from one or more dogs, please submit a separate order for those dogs once the samples are ready to be shipped.

Please follow specific shipping instructions provided in the Sample Collection Protocols linked above.

If the samples will be shipping from out of the USA, please follow these USDA Importation Procedures and include the required completed documents.

Additional Information

The Glycogen Storage Disease Test is a genetic test looking for the presence of genes associated with Glycogen Storage Disease in Basset Hounds.

Sample Submission Requires a Completed Submission Form and Online Payment
Download and complete the Canine Genetic Testing Submission Form from the ADDL website. One submission form will need to be completed for each dog unless the test is for a litter. In the case of a litter, you may complete the Canine Genetic Testing Litter Submission Form.
Include a printed copy of the completed submission form and paid receipt with the sample submission. Testing will NOT begin until payment has been received in full. You will receive a copy of the receipt in the confirmation email once the checkout process has completed.

Pricing
Individual Tests:
1-3 Dogs: $70.00 for each dog
4 or more: $63.00 for each dog

Payment
Once the submission form(s) has been completed, please go to the ADDL Genetic Testing Payment website to submit payment PRIOR TO SHIPPING ANY SAMPLES. Please note, the payment website will timeout if inactive for 15 minutes without saving/submitting information. You will need to enter the name and sex of each dog as one of the online form steps. Please have this information ready to prevent a system timeout from occurring.

Select the name of the correct testing option for payment based on individual vs combo test and quantity of dogs getting that specific test order. Individual tests are to be used if it is the only test that a specific dog will be tested for. Combo tests are to be used when a specific dog will get tested for the combination of tests included with that combo. To ensure price breaks work accurately, please chose the 1-3 dogs testing option or the 4+ dogs testing option based on the number of dogs you are submitting samples for on that specific testing option. For questions, please contact the ADDL by phone at 765-494-7440 or email addl@purdue.edu.

Results
Please view the Glycogen Storage Disease Result Interpretation page for information explaining the meaning of report results.

Condition Information

Basset Hound Glycogen Storage Disease (BHGSD)

An inherited metabolic disease, specifically a Glycogen Storage Disease, has been reported in Basset Hounds (BHGSD). Cases have been confirmed by post-mortem examination by board certified veterinary pathologists.

This condition proceeds in a gradual, subtle way, but with harmful effects; affected dogs typically appear healthy until they suddenly are not, which can be anywhere between 3-6 years of age. This is particularly challenging because affected dogs may have been bred prior to showing any signs of disease. Clinical signs can be subtle to non-existent and can be very difficult to notice. The first sign something is wrong can be sudden death of the dog. If warning signs are observed, they can include lethargy, exercise intolerance, and laziness (although this is certainly a “tough call” in some Basset Hounds, who can be inclined toward sedentary lifestyles already), heavy/labored breathing and other signs of cardiac disease, including an enlarged heart on imaging (radiographs/X-rays and/or ultrasound/echocardiogram). Some affected dogs had other disorders, including gastrointestinal problems and inflammation of the central nervous system, however, the main cause of death is heart failure due to the accumulation of abnormal glycogen.

BHGSD is a metabolic disease where glycogen, an energy storage product in the body, accumulates abnormally and excessively in several different tissues, including the heart. Autopsy of deceased cases identified significantly elevated amounts of glycogen in the cells of the heart muscle, which ultimately results in the dog’s heart failing.

Research carried out at Purdue University indicates that this disease is inherited in an autosomal recessive manner. We have identified a mutation within a disease-associated gene, and all affected dogs have two copies of this mutation. We are now offering a genetic test which allows owners to determine their dog’s status for this mutation (clear, carrier, or affected) in order to diagnose affected dogs and to guide future breeding decisions. Carriers do not need to be removed from the breeding population; however, they should only be bred to clear mates to avoid producing affected offspring.