Harm HogenEsch, DVM, PhD

Department of Veterinary Administration /
Department of Comparative Pathobiology

Purdue University College of Veterinary Medicine
625 Harrison Street
West Lafayette, IN 47907

Phone: 765.496.3487
Email: hogenesch@purdue.edu

The HogenEsch Research Group | PVM Leadership | Office of Research

Education

1989 - PhD | University of Illinois
1984 - DVM | University of Utrecht

Certification

Diplomate, American College of Veterinary Pathologists

Areas of Interest

Mucosal immunology and mucosal vaccines
Adjuvants
Dendritic cells
Immunobiology of the skin

Experience

2008 - | Associate Dean for Research and Graduate Programs, College of Veterinary Medicine, Purdue University, West Lafayette, IN.
2001 - | Professor of Immunopathology, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN.
2001 - 2008 | Head, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN.
1997 - 2001 | Associate Professor of Immunopathology, Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN.
1994 - 1997 | Assistant Professor of Immunopathology, Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN.
1993 - 1994 | Visiting Assistant Professor of Immunopathology, Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN.
1989 - 1993 | Pathologist, Institute for Ageing and Vascular Research, TNO, Leiden, the Netherlands.
1985 - 1989 | Teaching Assistant in Anatomical Pathology, Department of Veterinary Pathobiology, University of Illinois, Urbana, IL.

Selected Publications

– HogenEsch H, Gijbels MJJ, Offerman E, Van Hooft J, Van Bekkum DW, Zurcher, C (1993) A spontaneous mutation characterized by chronic proliferative dermatitis (cpd) in C57BL/Ka mice. Am J Pathol, 143:972-982.

– HogenEsch H, Janke S, Boggess D, Sundberg JP (1999) Absence of Peyer's patches and abnormal lymphoid microarchitecture in chronic proliferative dermatitis (cpdm/cpdm) mice. J Immunol, 162:3890-3896.

– Seymour R, Hasham MG, Cox GA, Shultz LD, HogenEsch H, Roopenian DC, Sundberg JP (2007) Spontaneous mutations in the mouse Sharpin gene result in multi-organ inflammation, immune system dysregulation, and dermatitis. Genes Immun, 8:416-421.

– Sokolovska A, Hem SL, HogenEsch H (2007) Activation of dendritic cells and induction of CD4+ T cell differentiation by aluminum-containing adjuvants. Vaccine, 25:4575-4585.

– Wang Z, Sokolovska A, Seymour R, Sundberg JP, HogenEsch H (2012) SHARPIN Is essential for cytokine production, NF-?B signaling, and induction of Th1 differentiation by dendritic cells. PLoS One, 7:e31809.

– Wang Z, Potter CS, Sundberg JP, HogenEsch H (2012) SHARPIN is a key regulator of immune and inflammatory responses. J Cell Mol Med, 16:2271-2279.

– Lu F, HogenEsch H (2013) Kinetics of inflammation following injection of aluminum-adjuvanted vaccines. Vaccine, 31: 3979-3986.

– HogenEsch H (2013) Mechanism of immunopotentiation and safety of aluminum adjuvants. Front Immunol, 3:406.

– Lu F, Mencia A, Bi L, Taylor A, Yao Y, HogenEsch H (2015) Dendrimer-like alpha-D-glucan nanoparticles activate dendritic cells and are effective vaccine adjuvants. J Control Release, 204: 51-59.

– Chien SJ, Silva KA, Kennedy VE, HogenEsch H, Sundberg JP (2015) The pathogenesis of chronic eosinophilic esophagitis in SHARPIN-deficient mice. Exp Mol Pathol 99:460-467.

– Lu F, Mosley Y, Rosales RR, Carmichael BE, Elesela S, Yao Y, HogenEsch H (2017) Alpha-D-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells. Npj Vaccines, 2:4.

– Mosley YYC, Radder JE, Berndt A, HogenEsch H (2017) Genome-wide association mapping of the antibody response to diphtheria-tetanus-acellular pertussis vaccine in mice. J Infectious Dis, 215:466-474.