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College of Veterinary Medicine

Harm HogenEsch, DVM, PhD, Diplomate ACVP

  • Veterinary Administration Department / Department of Comparative Pathobiology
  • Associate Dean for Research
  • Professor of Immunopathology
  • Purdue University College of Veterinary Medicine
  • 625 Harrison Street
  • West Lafayette, IN 47907



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Education

  • 1989 - PhD | University of Illinois
  • 1984 - DVM | University of Utrecht

Experience

  • 2008 - | Associate Dean for Research and Graduate Programs, College of Veterinary Medicine, Purdue University, West Lafayette, IN.
  • 2001 - | Professor of Immunopathology, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN.
  • 2001 - 2008 | Head, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN.
  • 1997 - 2001 | Associate Professor of Immunopathology, Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN.
  • 1994 - 1997 | Assistant Professor of Immunopathology, Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN.
  • 1993 - 1994 | Visiting Assistant Professor of Immunopathology, Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN.
  • 1989 - 1993 | Pathologist, Institute for Ageing and Vascular Research, TNO, Leiden, the Netherlands.
  • 1985 - 1989 | Teaching Assistant in Anatomical Pathology, Department of Veterinary Pathobiology, University of Illinois, Urbana, IL.

Selected Publications

  • HogenEsch H, Gijbels MJJ, Offerman E, Van Hooft J, Van Bekkum DW, Zurcher, C (1993) A spontaneous mutation characterized by chronic proliferative dermatitis (cpd) in C57BL/Ka mice. Am J Pathol, 143:972-982.
  • HogenEsch H, Janke S, Boggess D, Sundberg JP (1999) Absence of Peyer's patches and abnormal lymphoid microarchitecture in chronic proliferative dermatitis (cpdm/cpdm) mice. J Immunol, 162:3890-3896.
  • HogenEsch H, Torregrosa SE, Boggess D, Sundberg BA, Carroll J, Sundberg JP (2001) Increased expression of type 2 cytokines in chronic proliferative dermatitis (cpdm) mutant mice and resolution of inflammation following treatment with IL-12. Eur J Immunol, 31:734-742.
  • HogenEsch H (2002) Mechanisms of stimulation of the immune response by aluminum adjuvants. Vaccine, 20:S34 - S39.
  • Morefield GL, Sokolovska A, Jiang D, HogenEsch H, Robinson JP, Hem SL (2005) Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro. Vaccine, 23: 1588-95.
  • HogenEsch H, Dunham A, Seymour R, Renninger ML, Sundberg JP (2006) Expression of chitinase-like proteins in the skin of chronic proliferative dermatitis (cpdm/cpdm) mice. Exp Dermatol, 15:808-814.
  • Seymour R, Hasham MG, Cox GA, Shultz LD, HogenEsch H, Roopenian DC, Sundberg JP (2007) Spontaneous mutations in the mouse Sharpin gene result in multi-organ inflammation, immune system dysregulation, and dermatitis. Genes Immun, 8:416-421.
  • Sokolovska A, Hem SL, HogenEsch H (2007) Activation of dendritic cells and induction of CD4+ T cell differentiation by aluminum-containing adjuvants. Vaccine, 25:4575-4585.
  • Hem SL, HogenEsch H (2007) Aluminum-containing vaccine adjuvants (Invited review). Expert Rev Vaccines, 6:685-698.
  • Renninger ML, Seymour RE, Whiteley LO, Sundberg JP, HogenEsch H (2010) Anti-IL5 decreases the number of eosinophils but not the severity of dermatitis in SHARPIN-deficient mice. Exp Dermatol, 19:252-258.
  • Wang Z, Sokolovska A, Seymour R, Sundberg JP, HogenEsch H (2012) SHARPIN Is essential for cytokine production, NF-?B signaling, and induction of Th1 differentiation by dendritic cells. PLoS One, 7:e31809.
  • Wang Z, Potter CS, Sundberg JP, HogenEsch H (2012) SHARPIN is a key regulator of immune and inflammatory responses. J Cell Mol Med, 16:2271-2279.
  • Lu F, Boutselis I, Borch RF, HogenEsch H (2013) Control of antigen-binding to aluminum adjuvants and the immune response with a novel phosphonate linker. Vaccine, 31:4362-4367.
  • Lu F, HogenEsch H (2013) Kinetics of inflammation following injection of aluminum-adjuvanted vaccines. Vaccine, 31: 3979-3986.
  • Seymour R, Shirley B, HogenEsch H, Shultz LD, Sundberg JP (2013) Loss of function of the mouse Sharpin gene results in Peyer's patch regression. PLoS One, 8:e55224.
  • HogenEsch H (2013) Mechanism of immunopotentiation and safety of aluminum adjuvants. Front Immunol, 3:406.
  • Potter CS, Wang Z, Silva KA, Kennedy VE, Stearns TM, Burzenski L, Shultz LD, HogenEsch H, Sundberg JP (2014). Chronic proliferative dermatitis in Sharpin null mice: development of an autoinflammatory disease in the absence of B and T lymphocytes and IL4/IL13 signaling. PLoS ONE 9:e85666