PVM Directory / Harm HogenEsch
Harm HogenEsch, DVM, PhD, DACVP
Contact Info
Distinguished Professor of Immunopathology
Department of Comparative Pathobiology
Purdue University College of Veterinary Medicine
625 Harrison Street
West Lafayette, IN 47907
765-494-0854
hogenesch@purdue.edu
The HogenEsch Research Group | Purdue Institute of Inflammation, Immunology and Infectious Disease | National Library of Medicine Publications
Education
1989 - PhD | University of Illinois
1984 - DVM | University of Utrecht
Experience
2008–2024 | Associate Dean for Research and Graduate Programs, College of Veterinary Medicine, Purdue University, West Lafayette, IN.
2001 | Professor of Immunopathology, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN.
2001–2008 | Head, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN.
1997–2001 | Associate Professor of Immunopathology, Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN.
1994–1997 | Assistant Professor of Immunopathology, Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN.
1993–1994 | Visiting Assistant Professor of Immunopathology, Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN.
1989–1993 | Pathologist, Institute for Ageing and Vascular Research, TNO, Leiden, the Netherlands.
1985–1989 | Teaching Assistant in Anatomical Pathology, Department of Veterinary Pathobiology, University of Illinois, Urbana, IL.
Certifications
- Diplomate, American College of Veterinary Pathologists
Areas of Interest
- Mucosal immunology and mucosal vaccines
- Adjuvants
- Dendritic cells
- Immunobiology of the skin
- Toxicology
- Immunology
Selected Publications
- HogenEsch H, Gijbels MJJ, Offerman E, Van Hooft J, Van Bekkum DW, Zurcher, C (1993) A spontaneous mutation characterized by chronic proliferative dermatitis (cpd) in C57BL/Ka mice. Am J Pathol, 143:972-982.
- HogenEsch H, Janke S, Boggess D, Sundberg JP (1999) Absence of Peyer's patches and abnormal lymphoid microarchitecture in chronic proliferative dermatitis (cpdm/cpdm) mice. J Immunol, 162:3890-3896.
- Seymour R, Hasham MG, Cox GA, Shultz LD, HogenEsch H, Roopenian DC, Sundberg JP (2007) Spontaneous mutations in the mouse Sharpin gene result in multi-organ inflammation, immune system dysregulation, and dermatitis. Genes Immun, 8:416-421.
- Sokolovska A, Hem SL, HogenEsch H (2007) Activation of dendritic cells and induction of CD4+ T cell differentiation by aluminum-containing adjuvants. Vaccine, 25:4575-4585.
- Wang Z, Sokolovska A, Seymour R, Sundberg JP, HogenEsch H (2012) SHARPIN Is essential for cytokine production, NF-?B signaling, and induction of Th1 differentiation by dendritic cells. PLoS One, 7:e31809.
- Wang Z, Potter CS, Sundberg JP, HogenEsch H (2012) SHARPIN is a key regulator of immune and inflammatory responses. J Cell Mol Med, 16:2271-2279.
- Lu F, HogenEsch H (2013) Kinetics of inflammation following injection of aluminum-adjuvanted vaccines. Vaccine, 31: 3979-3986.
- HogenEsch H (2013) Mechanism of immunopotentiation and safety of aluminum adjuvants. Front Immunol, 3:406.
- Lu F, Mencia A, Bi L, Taylor A, Yao Y, HogenEsch H (2015) Dendrimer-like alpha-D-glucan nanoparticles activate dendritic cells and are effective vaccine adjuvants. J Control Release, 204: 51-59.
- Chien SJ, Silva KA, Kennedy VE, HogenEsch H, Sundberg JP (2015) The pathogenesis of chronic eosinophilic esophagitis in SHARPIN-deficient mice. Exp Mol Pathol 99:460-467.
- Lu F, Mosley Y, Rosales RR, Carmichael BE, Elesela S, Yao Y, HogenEsch H (2017) Alpha-D-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells. Npj Vaccines, 2:4.
- Mosley YYC, Radder JE, Berndt A, HogenEsch H (2017) Genome-wide association mapping of the antibody response to diphtheria-tetanus-acellular pertussis vaccine in mice. J Infectious Dis, 215:466-474.