College of Veterinary Medicine

PVM Directory / Suresh K. Mittal

Suresh K. Mittal, DVM, PhD

Suresh K. Mittal, DVM, PhD

Distinguished Professor of Virology
University Faculty Scholar
Member of Purdue Cancer Center
Member of Bindley Bioscience Center

Department of Comparative Pathobiology
Purdue University College of Veterinary Medicine
625 Harrison Street
West Lafayette, IN 47907

765-496-2894
mittal@purdue.edu

Purdue Institute of Inflammation, Immunology and Infectious Diseases | National Library of Medicine Publications

Education

1989 - PhD | University of Cambridge
1984 - MS | Haryana Agricultural University
1982 - DVM | Haryana Agricultural University

Areas of Interest

  • Microbiology
  • Virology

Selected Publications

  • Tandon M., Vemula S. and Mittal S. K. (2011). Emerging strategies for EphA2 receptor targeting for cancer therapeutics. Expert Opin Ther Targets. 15(1):31-51.
  • Sharma A., Bangari D. S., Tandon M., Pandey A., HogenEsch H. and Mittal S. K. (2010). Evaluation of innate immunity and vector toxicity following intravenous inoculation of bovine, porcine and human adenoviral vectors in a mouse model. Virus Res. 153:134-
  • Vemula S. and Mittal S. K. (2010). Production of adenovirus vectors and their use as a delivery system for influenza vaccines. Expert Opin Biol Ther. 10(10):1469-87.
  • Sharma A., Tandon M., Ahi Y., Bangari D. S., Vemulapalli R and Mittal S. K. (2010). Evaluation of Cross-Reactive Humoral and Cell-Mediated Immune Responses among Human, Bovine and Porcine Adenoviruses. Gene Ther. 153(1):134-42. PMCID: PMC2869393 [Availabl
  • Singh N., Pandey A., Sambhara S. and Mittal S. K. (2010). Avian influenza pandemic preparedness: developing prepandemic and pandemic vaccines against a moving target. Expert Reviews in Molecular Medicine. Apr 29;12:e14.
  • Pandey A, Singh N, Sambhara S and Mittal SK. (2010). Egg-independent vaccine strategies for highly pathogenic H5N1 influenza viruses. Human Vaccine. 6(2):178-188. PMCID: PMC2888842 [Available on 2011/8/1]
  • Li X., Bangari D. S., Sharma A. and Mittal S. K. (2009) Bovine adenovrius serotype 3 utilizes sialic acid as a cellular receptor for virus entry. Virology. 392(2):162-168. PMCID: PMC2743766 [Available on 2010/9/30]
  • Sharma A, Li, X., Bangari, D. S. and Mittal, S. K. (2009). Adenovirus receptors and their implications in gene delivery. Virus Res. 143(2):184-94.
  • Sharma, A., Bangari, D. S., Tandon, M., Pandey, A., HogenEsch, H. and Mittal, S. K. (2009). Comparative analysis of vector biodistribution, persistence and gene expression following intravenous delivery of bovine, porcine and human adenoviral vectors in a
  • Singh, N., Pandey, A., Jayashankar, L.. and Mittal, S. K. (2008). Bovine adenoviral vector-based H5N1 influenza vaccine overcomes exceptionally high levels of pre-existing immunity against human adenovirus. Mol. Ther. 16:965-971.
  • Hoelscher, M. A., Singh, N., Garg, S., Jayashankar, L., Veguilla, V., Pandey, A., Matsuoka, Y., Katz, J. M., Donis, R., Mittal, S. K. and Sambhara, S. (2008). A broadly protective vaccine against globally dispersed clade 1 and clade 2 H5N1 influenza virus
  • Hoelscher, M. A., Jayashankar, L., Garg, S. Veguilla, V., Lu, X., Singh, N., Katz, J. M., Mittal, S. K. and Sambhara S. (2007). New pre-pandemic influenza vaccines: An egg- and adjuvant-independent human adenoviral vector strategy induces long lasting pro
  • Mittal, S. K. (2007). Respiratory viruses of animals causing disease in humans - Keystone Symposium. IDrugs 10:156-158.
  • Hoelscher, M. A., Garg, S., Bangari, D. S., Belser, J., Lu, X., Stephenson, I., Bright, R. A., Katz, J. M., Mittal, S. K. and Sambhara, S. (2006). Development of adenoviral-vector-based pandemic influenza vaccine against antigenically distinct human H5N1
  • Bangari, D. S. and Mittal, S. K.(2006). Current strategies and future directions for eluding adenoviral vector immunity. Curr. Gene Ther. 6:215-226.
  • Bangari, D. S. and Mittal, S. K. (2006). Development of nonhuman adenoviruses as vaccine vectors. Vaccine 24:849-862.
  • Bangari, D. S., Sharma, A. and Mittal, S. K. (2005). Bovine adenovirus type 3 internalization is independent of primary receptors of human adenovirus type 5 and porcine adenovirus type 3. Biochem. Biophys. Res. Commun. 331:1478-1484.
  • Bangari, D. S., Shukla, S. and Mittal, S. K. (2005). Comparative transduction efficiencies of human and nonhuman adenoviral vectors in human, murine, bovine, and porcine cells in culture. Biochem. Biophys. Res. Commun. 327:960-966.
  • Bangari, D. S. and Mittal, S. K. (2005). Porcine adenovirus serotype 3 internalization is independent of CAR and avb3 or avb5 integrin.Virology 332:157-166.
  • Noblitt, L. W., Bangari, D. S., Shukla, S., Mohammed, S. and Mittal, S. K. (2005). Immunocompetent mouse model of breast cancer for preclinical testing of EphA2-targeted therapy. Cancer Gene Ther. 12:46-53.
  • Noblitt, L. W., Bangari, D. S., Shukla, S., Knapp, D. W., Mohammed, S., Kinch, M. S. and Mittal, S. K. (2004). Decreased tumorigenic potential of EphA2-overexpressing breast cancer cells following treatment with adenoviral vectors that express EphrinA1. C
  • Bangari, D. S. and Mittal, S. K. (2004). Porcine adenoviral vectors evade preexisting humoral immunity to adenoviruses and efficiently infect both human and murine cells in culture.Virus Res. 105:127-36.
  • Sailaja, G., HogenEsch, H., North, A., Hays, J. and Mittal, S. K. (2002). Encapsulation of recombinant adenovirus into alginate microspheres circumvents vector specific immune response. Gene Ther. 9:1722-1729.
  • van Olphen, A. L. and Mittal, S. K. (2002). Development and characterization of bovine x human hybrid cell lines that efficiently support the replication of both wild-type and E1-deleted bovine and human adenoviruses. J. Virol. 76: 5882-5892.
  • van Olphen, A. L., Tikoo, S. K. and Mittal, S. K. (2002). Characterization of bovine adenovirus type 3 early region 1 (E1) proteins and isolation of E1 expressing cell lines. Virology 295:108-118.
  • Aggarwal, N. and Mittal, S. K. (2000). Sequence analyses of porcine adenovirus type 3 E1 region, pIX, and pIVa2 genes. Intervirology 43:6-12.
  • Mittal, S. K., Aggarwal, N., Sailaja, G., van Olphen, A. L., HogenEsch, H., North, A., Hays, J. and Moffatt, S. (2000). Immunization with DNA, adenovirus or both in biodegradable alginate microspheres: effect of route of inoculation on immune response. Va
  • Moffatt, S., HogenEsch, H., Hays, J. and Mittal, S. K. (2000). Circumvention of vector-specific antibody response by alternating use of human and non-human adenoviruses: implications in gene therapy. Virology 272:159-167.
  • Mittal, S. K., Tikoo, S. K., van Donkersgoed, J., Godson, D. L. and Babiuk, L. A. (1999). Experimental inoculation of heifers with bovine adenovirus type 3. Can. J. Vet. Res. 63:153-156.
  • van Olphen, A. L. and Mittal, S. K. (1999). Generation of infectious genome of bovine adenovirus type 3 by homologous recombination in bacteria. J. Virol. Methods 77:125-129.
  • Aggarwal, N., HogenEsch, H., Guo, P., Adam North, Suckow, M. and Mittal, S. K. (1999). Biodegradable alginate microspheres as a delivery system for naked DNA. Can. J. Vet. Res. 63:148-152.
  • Mittal, S. K., Tikoo, S. K., van den Hurk, J. V., Breker-Klassen, M. M., Yoo, D. and Babiuk, L. A. (1998). Functional characterization of bovine parainfluenza virus type 3 hemaggutinin-neuraminidase and fusion proteins expressed by adenovirus recombinants
  • Papp, Z., Middleton, D. M., Mittal, S. K., Babiuk, L. A. and Baca-Estrada, M. E. (1997). Mucosal immunization with recombinant adenovirus vectors: Induction of immunity and protection against respiratory bovine herpesvirus type 1 in the cotton rat model.
  • Torres, J. M., Alonso, C., Ortega, A., Mittal, S. K., Graham, F. L. and Enjuanes, L. (1996). Tropism of human adenovirus 5 based vectors in swine and their ability to protect against transmissible gastroenteritis coronavirus. J. Virol. 70: 3770-3780.
  • Mittal, S. K., Middleton, D. M., Tikoo, S. K., Prevec, L., Graham, F. L. and Babiuk, L. A. (1996). Pathology and immunogenicity in the cotton rat (Sigmodon hispidus) model following infection with a bovine adenovirus type 3 recombinant virus expressing th
  • Mittal, S. K., Papp, Z., Tikoo, S. K., Baca-Estrada, M., Yoo, D., Benko, M. and Babiuk, L. A. (1996). Induction of systemic and mucosal immune responses in cotton rats immunized with human adenovirus type 5 recombinants expressing the full and secretory f
  • Mittal, S. K., Bett, A. J., Prevec, L. and Graham, F L. (1995). Foreign gene expression by human adenovirus type 5 based vectors studied using firefly luciferase and bacterial beta-galactosidase genes as reporters. Virology 210:226-230.
  • Mittal, S. K., Prevec, L., Graham, F. L. and Babiuk, L. A. (1995). Development of a bovine adenovirus-based expression vector. J. Gen. Virol. 76:93-102.
  • Breker-Klassen, M. M., Yoo, D., Mittal, S. K., Sorden, S. D., Haines, D. M. and Babiuk, L. A. (1995). Recombinant adenoviruses type 5 expressing bovine parainfluenza virus type 3 glycoproteins protect Sigmodon hispidus cotton rats from bovine parainfluenz
  • Mittal, S. K., Middleton, D. M., Tikoo, S. K. and Babiuk, L. A. (1995). Pathogenesis and immunogenicity of bovine adenovirus type 3 in cotton rats (Sigmodon hispidus). Virology 213:131-139.
  • • Sayedahmed EE, Kumari R, Shukla S, Hassan AO, Mohammed SI, York IA, Gangappa S, Sambhara S, Mittal SK. Longevity of adenovirus vector immunity in mice and its implications for vaccine efficacy. Vaccine. 2018 Sep 25. pii: S0264-410X(18)31291-X. doi: 10.1016/j.vaccine.2018.09.031. [Epub ahead of print]
  • • Sayedahmed EE, Hassan AO, Kumari R, Cao W, Gangappa S, York I, Sambhara S, Mittal SK. A Bovine Adenoviral Vector-Based H5N1 Influenza -Vaccine Provides Enhanced Immunogenicity and Protection at a Significantly Low Dose. Mol Ther Methods Clin Dev. 2018 Jul 17;10:210-222. doi: 10.1016/j.omtm.2018.07.007. eCollection 2018 Sep 21.
  • • Hassan AO, Amen O, Sayedahmed EE, Vemula SV, Amoah S, York I, Gangappa S, Sambhara S, Mittal SK. Adenovirus vector-based multi-epitope vaccine provides partial protection against H5, H7, and H9 avian influenza viruses. PLoS One. 2017 Oct 12;12(10):e0186244. doi: 10.1371/journal.pone.0186244. eCollection 2017.
  • • Vemula SV, Sayedahmed EE, Sambhara S, Mittal SK. Vaccine approaches conferring cross-protection against influenza viruses. Expert Rev Vaccines. 2017 Nov;16(11):1141-1154. doi: 10.1080/14760584.2017.1379396. Epub 2017 Sep 19. Review.
  • • Sayedahmed E.E., Kumari R., Mittal S.K. (2019) Current Use of Adenovirus Vectors and Their Production Methods. In: Manfredsson F., Benskey M. (eds) Viral Vectors for Gene Therapy. Methods in Molecular Biology, vol 1937. Humana Press, New York, NY