Canine Patient Recruitment

As of June 21, 2016

If you would like additional information regarding a clinical trial, please contact us at:

Email: VeterinaryClinicalTrials@purdue.edu
Phone: (765) 496-9715
Fax: (765) 496-1108

If you believe your pet is eligible for a specific study, we recommend that you contact your veterinarian and request a referral. However, a referral is not required to participate in a clinical trial.

To make an appointment at the Small Animal Hospital please call (765) 494-1107.

Behavior

Canine Aggression Study in Labrador Retriever, Beagle and Standard Poodle

  • Description: This study is to compare genetic and behavior information between human directed aggressive dogs and non-aggressive (to both humans and animals) dogs in three different breeds to see if potential genetic and/or biomarkers may be identified.
  • Eligibility: Pure bred Labrador Retrievers, Beagles, or Standard Poodles that are either affected dogs (human aggressive dogs) or control dogs (no aggression toward humans or animals) are eligible.
  • Financial Incentive: No cost for collection of samples (blood). Blood collection can also be performed at the primary veterinarian office and shipped to us (cost for blood collection and shipping will be covered).
  • Primary Investigator: Dr. Niwako Ogata

Separation Anxiety Disorder and Non-Separation Anxiety Disorder Dogs

  • Description: A study to develop biomarkers to assess anxiety disorders in dogs.
  • Eligibility: Clinically healthy dogs that must be neutered/spayed and between the ages of 1.5-7 years old. All participants (either separation anxiety dogs or non-anxious dogs) will be pre-screened for eligibility through a questionnaire and a 30-minute video clip at home.
  • Financial Incentive: No cost for collection of samples (blood).
  • Primary Investigator: Dr. Niwako Ogata

Behavioral and Physiological Responses in Dogs Under Social Anxiety

  • Description: A study to compare behavioral and physiological responses to identify the dogs at risk of social anxiety (both home and an exam room environment).
  • Eligibility: Clinically healthy dogs that must be neturered/spayed and between the ages of 1-13 years old can participate in the study.
  • Financial Incentive: No cost for collection of samples (saliva).
  • Primary Investigator: Dr. Niwako Ogata

Medicine

Dogs with Chronic Gastrointestinal Disease

  • Description: A collaboration study with Texas A&M to investigate and ultimately control chronic gastrointestinal diseases in dogs.
  • Eligibility: Any dog with chronic small intestinal enteropathies is eligible to enroll
  • Financial Incentive: The following diagnostics are covered by the study: GI panel (TLI, folate, cobalamin), histopathology, and all shipping costs.
  • Primary Investigator: Dr. Nolie Parnell

Neurology

MRI for Dogs Suspected to Have Brain Tumors

  • Description: A study to develop MRI in the diagnosis of dogs with brain tumors.
  • Eligibility: Any dog that is suspected to be suffering from a brain tumor. Examination by the Neurology & Neurosurgery service must confirm the suspicion of a brain tumor and eligibility for the study. Bloodwork and chest radiographs (from within the last month) must have already been performed – these may be performed at the referring veterinarian office before the appointment at Purdue.
  • Financial Incentive: The cost of the MRI is significantly reduced.
  • Primary Investigator: Dr. Timothy Bentley

Surgery and Metronomic Chemotherapy for Brain Tumors in Dogs

  • Description: Combination surgery and chemotherapy for brain tumors in dogs, including a post-operative MRI and a repeat MRI at three months. Samples to test the chemotherapy concentrations will be taken during the study.
  • Eligibility: Dogs that have been tentatively diagnosed with a brain tumor by MRI. Chest radiographs and bloodwork must also have been performed (within the last month). Other tests to assess general health may be required before dogs are eligible for enrollment.
  • Financial Incentives: The brain tumor surgery, the chemotherapy, the bloodwork to monitor the chemotherapy, and the two repeat MRIs will all be provided at no charge. (Dogs with inoperable brain tumors will be eligible for chemotherapy, bloodwork to monitor the chemotherapy and repeat MRI at three months, all provided at no charge).
  • Primary Investigators: Dr. Timothy Bentley

Oncology

Dogs with Transitional Cell Carcinoma

  • Description: This pilot study is to determine the antitumor effects and the toxicity (or lack thereof) of a folate-targeted therapy.
  • Eligibility: Biopsy diagnosis of naturally-occurring transitional cell carcinoma.
    • Confirmed folate receptor expression in the tumor
    • Measurable cancer lesions
    • Expected survival of six weeks
  • Financial Incentive: Folate-tubulysin will be provided by a drug company. Most of the expenses related to administering and monitoring the treatment will be paid by the study funding agency. Pet owners will be asked to pay a portion for expenses not covered by the trial.
  • Primary Investigator: Dr. Debbie Knapp

Healthy/Normal Dogs and Dogs Suspected or Confirmed of Having TCC that are Admitted to the Purdue Veterinary Teaching Hospital

  • Description: This study is to learn more about the transitional cell carcinoma of the urinary bladder in order to develop effective strategies to prevent TCC or to treat it more effectively. We wish to compare the results from dogs who are normal or who have other non-cancer problems in their urinary tract.
  • Eligibility: Healthy dogs or dogs with suspected or confirmed TCC that are at least one year of age and are admitted to the Purdue Veterinary Teaching Hospital.
  • Financial Incentive: No cost for collection of samples.
  • Primary Investigator: Dr. Debbie Knapp

Dogs with Lymphoma

  • Description: The purpose of this study is to investigate whether an innovative tissue imaging technology, known as biodynamic imaging (BDI), can be used to predict the responsiveness of canine diffuse large B-cell lymphoma (DLBCL) to chemotherapy. 
  • Eligibility: Biopsy- confirmed DLBCL diagnosis of lymphoma
    • No prior chemotherapy or radiation therapy, including prednisone
    • Expected survival of at least four weeks
    • Absence of other serious illness
    • Adequate bone marrow function in order to receive chemotherapy
  • Financial Incentive: Cost of biopsies and initial staging tests are paid for by the study.  Owners' financial responsibility for chemotherapy treatments is capped at $50 per visit to Purdue.  Pet owners are financially responsible for costs arising from medical management of treatment, as well as other medical conditions not related to Lymphoma.
  • Primary Investigator: Dr. Michael Childress

For more information on Oncology Clinical Investigations please visit their website at:http://www.vet.purdue.edu/pcop/

Ophthalmology

Dogs With Dry Eye Disease

  • Description: A study to evaluate the injection of stem cells derived from the dog's own fat into the diseased lacrimal glands to return functional tearing.
  • Eligibility: Dogs with documented dry eye that have responded poorly to standard treatment of topical cyclosporine or tacrolimus. Some dogs with extremely chronic lack of any tear production may not qualify for the study.
  • Financial Incentive: Reduced cost of laboratory preparation of stem cells.
  • Primary Investigator: Dr. Jean Stiles

Golden Retriever Pigmentary Uveitis (PU)

  • Description: A study to better understand the disease progression of PU and establish a DNA bank of samples from both affected and normal Golden Retrievers.
  • Eligibility: Any purebred Golden Retriever.
  • Financial Incentive: There is no compensation for participation in this study. However, the ocular examination is performed at no cost to you.
  • Primary Investigator: Dr. Wendy Townsend

Orthopedics

Polyarthritis – Folate-receptor Targeted Drug Delivery

  • Description: A study to evaluate a new folate-receptor drug complex for the treatment of immune mediated polyarthritis in dogs. The drug has strong anti-inflammatory activity, similar to the new rheumatoid arthritis drugs for humans.
  • Eligibility: Dogs with naturally occurring immune mediated polyarthritis.
  • Financial Incentive: All costs related to the diagnosis and rechecks through the 16 week recheck will be reimbursed to the owner. The owner is responsible for the cost of the initial visit for diagnosis. During this visit, the scintigraphy will be done free of charge. Once the diagnosis of immune mediated polyarthritis is made, the owner will be advised about eligibility for enrollment.
  • Primary Investigator: Dr. Gert Breur

    Purdue University College of Veterinary Medicine, 625 Harrison Street, West Lafayette, IN 47907, (765) 494-7607

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