{"id":6699,"date":"2019-11-22T12:00:58","date_gmt":"2019-11-22T17:00:58","guid":{"rendered":"https:\/\/qa.vet.purdue.edu\/news\/?p=6699"},"modified":"2019-11-22T12:00:58","modified_gmt":"2019-11-22T17:00:58","slug":"pvm-professors-contribute-to-research-on-potential-new-bladder-cancer-treatment","status":"publish","type":"post","link":"https:\/\/vet.purdue.edu\/news\/pvm-professors-contribute-to-research-on-potential-new-bladder-cancer-treatment.php","title":{"rendered":"PVM Professors Contribute to Research on Potential New Bladder Cancer Treatment"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Two Purdue Veterinary Medicine faculty members played an instrumental\nrole in research involving the Purdue University Center for Cancer Research focused\non developing a promising new method of treating bladder cancer using a\nmodified version of the anthrax toxin. Modifying the anthrax toxin makes it unlikely\nto cause harm to the patients. &nbsp;The new\napproach combines the toxin with a growth factor to kill bladder cancer cells.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignright is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/vet.purdue.edu\/news\/wp-content\/uploads\/2019\/11\/aguilar-dog-1-1024x639.jpg\" alt=\"a collection of bladder biopsy and scan images\" class=\"wp-image-6701\" width=\"400\" height=\"249\" srcset=\"https:\/\/vet.purdue.edu\/news\/wp-content\/uploads\/2019\/11\/aguilar-dog-1-1024x639.jpg 1024w, https:\/\/vet.purdue.edu\/news\/wp-content\/uploads\/2019\/11\/aguilar-dog-1-300x187.jpg 300w, https:\/\/vet.purdue.edu\/news\/wp-content\/uploads\/2019\/11\/aguilar-dog-1-768x479.jpg 768w, https:\/\/vet.purdue.edu\/news\/wp-content\/uploads\/2019\/11\/aguilar-dog-1-377x235.jpg 377w, https:\/\/vet.purdue.edu\/news\/wp-content\/uploads\/2019\/11\/aguilar-dog-1.jpg 1154w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><figcaption>Pet dogs with bladder cancer that had run out of other treatment options were treated with a Purdue University experimental approach. Image A shows a bladder cystoscopic biopsy being performed in a patient dog to investigate tumor characteristics.  Image B is an ultrasound image obtained to record tumor mass dimensions. In this sagittal view of the bladder, the arrows point to a mass in the neck of the bladder. Image C shows the presence of Epidermal Growth Factor (EGF) Receptor on bladder cancer cells, which was revealed by binding and uptake of fluorescently labeled EGF (red). The nucleus (blue) and actin cytoskeleton (green) are also shown. (Images provided)<\/figcaption><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">The lead investigator at Purdue is Dr. R. Claudio Aguilar, associate professor and assistant head of biological sciences in Purdue\u2019s College of Science.&nbsp; Dr. Aguilar\u2019s research group worked with Purdue teams led by Dr. Timothy Ratliff, distinguished professor of comparative pathobiology and the Robert Wallace Miller Director of the Purdue Center for Cancer Research, and Dr. Deborah Knapp, the Dolores L. McCall Professor of Comparative Oncology and director of the Purdue Comparative Oncology Program, to conduct clinical testing.&nbsp; They tested the new agent in dogs with bladder cancer, specifically dogs that had failed to respond to other therapies or who could not receive other therapies. Following the treatment with the toxin, the tumors decreased in size and the dogs did not experience any bothersome side effects. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWe have effectively come up with a promising method to kill the\ncancer cells without harming the normal cells in the bladder,\u201d said Dr. Aguilar.&nbsp; \u201cIt is basically like creating a special\nsolution that targets cancer cells while leaving healthy cells alone.\u201d The\nresearch was published in the October 4 issue of the <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/ijc.32719\">International\nJournal of Cancer<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">According to the U.S. Centers for Disease Control and Prevention, bladder cancer strikes more than 74,000 people in the U.S. every year and about 17,000 die from the disease. Current treatments are expensive and invasive, often requiring patients to sit for hours at a time with a bladder full of an agent designed to kill cancer cells and tumors. &nbsp;In contrast, Dr. Aguilar said the Purdue system works within minutes to target the cancer cells in the bladder.&nbsp; He explained that the bladder has its own protective layer, which saves the good cells from the anthrax mixture, but offers no protection for the cancer cells and tumors.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Aguilar, who works as part of a team focused on cell\nidentity and signaling at the <a href=\"https:\/\/www.cancerresearch.purdue.edu\/\">Purdue\nUniversity Center for Cancer Research<\/a> says the\nnew treatment \u201c\u2026is fast and effective, both of which are critical\nfor people dealing with this devastating disease.\u201d The investigators are also encouraged\nby the initial studies in a small number of dogs with bladder cancer in which\nthe treatment resulted in some reduction in the tumor size, because bladder\ncancer in dogs often develops resistance to other treatments and can be as\ndifficult to treat as human bladder cancer. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The Purdue researchers think a similar treatment may\nhelp people and animals with other cancers, including those affecting the lungs\nor skin.&nbsp; The Purdue researchers also collaborated\nwith partners in the Indiana University School of Medicine, the Massachusetts\nInstitute of Technology and Harvard University, and worked with the Purdue\nResearch Foundation Office of Technology Commercialization to patent the new\ntreatments.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Two Purdue Veterinary Medicine faculty members played an instrumental role in research involving the Purdue University Center for Cancer Research focused on developing a promising new method of treating bladder cancer using a modified version of the anthrax toxin.<\/p>\n","protected":false},"author":7,"featured_media":6701,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[36,41,29,11],"tags":[1405,1404,123,533,26,56,1344,1406,1271,62],"class_list":["post-6699","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-faculty-staff","category-our-people","category-research","tag-anthrax-toxin","tag-bladder-cancer-research","tag-cpb","tag-deborah-knapp","tag-featured-story","tag-homepage","tag-purdue-center-for-cancer-research","tag-purdue-comparative-oncology-program","tag-timothy-ratliff","tag-vcs"],"acf":[],"_links":{"self":[{"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/posts\/6699","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/comments?post=6699"}],"version-history":[{"count":6,"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/posts\/6699\/revisions"}],"predecessor-version":[{"id":6713,"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/posts\/6699\/revisions\/6713"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/media\/6701"}],"wp:attachment":[{"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/media?parent=6699"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/categories?post=6699"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/tags?post=6699"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}