{"id":6614,"date":"2019-11-15T14:53:51","date_gmt":"2019-11-15T19:53:51","guid":{"rendered":"https:\/\/qa.vet.purdue.edu\/news\/?p=6614"},"modified":"2026-05-13T13:42:56","modified_gmt":"2026-05-13T17:42:56","slug":"pvm-led-research-on-the-blood-brain-barrier-featured-on-cover-of-scientific-journal","status":"publish","type":"post","link":"https:\/\/vet.purdue.edu\/news\/pvm-led-research-on-the-blood-brain-barrier-featured-on-cover-of-scientific-journal.php","title":{"rendered":"PVM-led Research on the Blood-Brain Barrier Featured on Cover of Scientific Journal"},"content":{"rendered":"
\n
\"Dr.
Dr. Tiffany Lyle, assistant professor of veterinary anatomic pathology at Purdue University, led research that has provided the first comprehensive characterization of both the blood-brain and blood-tumor barriers in brain metastases of lung cancer, which will serve as a road map for treatment development. (Purdue University photo\/Rebecca Wilcox)<\/figcaption><\/figure>\n<\/div>\n\n\n

The most recently published research by the Comparative Blood-Brain Barrier Laboratory (CBBBL) in Purdue Veterinary Medicine\u2019s Department of Comparative Pathobiology, was featured on the cover of Oncotarget<\/a><\/em>, a peer-reviewed bio-medical journal. \u00a0Dr. Gozde Uzunalli, postdoctoral research associate, was the first author of the article<\/a>, which highlighted how the blood-brain barrier transitions into the blood-tumor barrier when it is disturbed by cancer cells. \u201cWe hope to be able use these results to increase drug delivery to metastatic brain lesions,\u201d said Dr. Uzunalli, who has received two postdoctoral awards for her work at the CBBBL.<\/p>\n\n\n\n

The research was led by Dr. Tiffany Lyle, assistant\nprofessor of veterinary anatomic pathology, whose work focuses on the pathology\nof the blood-brain barrier. As the principal investigator of the Comparative\nBlood-Brain Barrier Laboratory, she and her team have collaborated with other scientists\nat Purdue as well as the Indiana University Simon Cancer Center.  <\/p>\n\n\n

\n
\"Cover
Research conducted in Purdue Veterinary Medicine\u2019s Comparative Blood-Brain Barrier Laboratory gained great visibility when it was published as the cover article in the most recent issue (Issue 59) of Oncotarget, a peer-reviewed bio-medical journal.<\/figcaption><\/figure>\n<\/div>\n\n\n

The CBBBL research has provided the first comprehensive\ncharacterization of both the blood-brain and blood-tumor barriers in brain\nmetastases of lung cancer, which will serve as a road map for treatment\ndevelopment. \u201cBrain metastases occur most frequently in patients diagnosed with\nbreast and lung cancer and melanoma,\u201d Dr. Lyle said. \u201cThese metastases have a\ndevastating survival rate, mostly because it\u2019s so difficult to get drugs into\nthe brain tissue because of the blood-brain barrier.\u201d  <\/p>\n\n\n\n

The transition of the blood-brain barrier into the\nblood-tumor barrier presents a roadblock for effective drug delivery to the\nbrain. The formation of the blood-tumor barrier has been insufficiently\ncharacterized in lung cancer until now, Dr. Lyle explained.<\/p>\n\n\n\n

\u201cWe wanted to see what changes in the blood-brain barrier were occurring rapidly and which ones were sustained over time,\u201d Dr. Lyle said. \u201cIdentifying those changes and pinpointing when they occur during the transition will be critical to developing treatment plans and being able to identify where, and when, cancer cells need to be targeted.\u201d<\/p>\n\n\n\n

Click here to read a complete news release about the research.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The most recently published research by the Comparative Blood-Brain Barrier Laboratory in Purdue Veterinary Medicine\u2019s Department of Comparative Pathobiology, was featured on the cover of Oncotarget, a peer-reviewed bio-medical journal. Dr. Gozde Uzunalli, postdoctoral research associate, was the first author of the article, which highlighted how the blood-brain barrier transitions into the blood-tumor barrier when it is disturbed by cancer cells. The research was led by Dr. Tiffany Lyle, assistant professor of veterinary anatomic pathology.<\/p>\n","protected":false},"author":7,"featured_media":6616,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[41,38,29,11,42],"tags":[1390,1393,123,8,26,1389,400,56,1392,1391,150,168,25],"class_list":["post-6614","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculty-staff","category-neuroscience","category-our-people","category-research","category-students","tag-blood-brain-barrier","tag-brain-metastases","tag-cpb","tag-faculty","tag-featured-story","tag-gozde-uzunalli","tag-graduate-student","tag-homepage","tag-lung-cancer","tag-oncotarget","tag-research","tag-tiffany-lyle","tag-top-story"],"acf":[],"_links":{"self":[{"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/posts\/6614","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/comments?post=6614"}],"version-history":[{"count":10,"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/posts\/6614\/revisions"}],"predecessor-version":[{"id":33906,"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/posts\/6614\/revisions\/33906"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/media\/6616"}],"wp:attachment":[{"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/media?parent=6614"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/categories?post=6614"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vet.purdue.edu\/news\/wp-json\/wp\/v2\/tags?post=6614"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}