Equine Asthma Workshop: Current Understanding and future directions

May 22-25, 2019 - Custer State Park, South Dakota

Sponsored by the

Sponsored by the Havemeyer Foundation

The effort to clarify the phenotype and terminology used to characterize horses with chronic inflammatory airway disease started in 2000 with a workshop in East Lansing, Michigan. Several workshops were subsequently held with similar goals in mind with the latest hosted in Cabourg, France in 2014. In the last couple of years, the terminology has further evolved with the term Equine Asthma now being recommended to describe horses with chronic respiratory signs ranging in severity from severe to mild that were previously referred to recurrent airway obstruction and inflammatory airway disease, respectively. The goal of the 2019 Equine Asthma Workshop is to attract researchers and clinicians from around the world who are actively investigating airway inflammation. We will discuss the latest contributions to the understanding of asthma in horses and other species. The workshop format will facilitate  productive discussions that will inform potential future revisions of the 2016 ACVIM consensus statement and provide future research directions.

Workshop Schedule

Wednesday May 22nd, 2019

6:00 - 9:00 PM Welcome Reception

Thursday, May 23rd, 2019 - Equine vs. Human Asthma: Definitions and Diagnosis

Morning Session - Moderator: Laurent Couetil
8:10 – 8:25 AM Introductory remarks by Gene Pranzo & Laurent Couetil
8:25 – 8:50 AM Clinical and molecular phenotypes of human asthma by Jim Martin
8:50 – 9:15 AM Phenotypes and endotypes of equine asthma: is the 2016 ACVIM consensus statement definition of EA still valid? by Jean-Pierre Lavoie
9:15 – 9:35 AM Summer-pasture RAO phenotype and triggers by Cyprianna Swiderski
9:35 – 10:00 AM Recommended minimum database for diagnosis of EA by equine practitioners in the field vs. criteria used for research? by Melissa Mazan
10:00 – 10:20 AM Break
10:20 – 11:00 AM Research abstracts (10-15 min/abstract)
11:00 – Noon Round table discussion
Noon - 1:00 PM Lunch
Afternoon Session - Moderator: Jackie Cardwell
1:00 – 1:20 PM Health effects of equine asthma by Laurent Couetil
1:20 – 1:40 PM Tissue remodeling in EA and functional consequences by Michela Bullone
1:40 – 2:00 PM Equine asthma from the practitioner’s perspective: Perception and practices by Jackie Cardwell
2:00 – 2:40 PM Research abstracts (10-15 min/abstract)
2:40 – 2:50 PM Break
2:50 – 3:30 PM Round table discussion
Evening / Social activities
4:00 PM Buffalo Safari Jeep Tour followed by dinner

Friday, May 24th, 2019 - Etiology & Pathophysiology of Equine Asthma

Morning session - Moderator: Eric Richard
8:00 – 8:20 AM Mucosal immune defenses of the respiratory tract against infectious and non-infectious invaders by Romain Paillot
8:20 – 8:40 AM Role of microbiome in equine asthma by Renaud Leguillette
8:40 – 9:00 AM Role of viruses in equine asthma by Nicolas Pusterla
9:00 – 9:20 AM Role of non-infectious exposures in equine asthma by Katy Ivester
9:20 – 9:40 AM Extracellular vesicles in asthma by Andrew Hoffman
9:40 – 10:00 AM Round Table discussion
10:00 – 10:15 AM Coffee break
10:15 – 10:35 AM Is the neutrophil a key player in equine asthma? by Gabriel Moran
10:35 – 10:55 AM Insights into equine asthma pathophysiology from transcriptomics by Dorothee Bienzle
10:55 – 11:15 AM Is equine asthma an allergic disease? by Eliane Marti
11:15 – 11:35 AM Genetic risk factors of equine asthma by Vince Gerber
11:35 – Noon Round table discussion
Noon – 1:00 PM Lunch
Afternoon session - Moderator: Renaud Leguillette
1:00 – 1:40 PM Research abstracts (10-15 min/abstract; n=2-4)
1:40 – 3:30 PM

Rotating round table discussion

Each group will spend approximately 30 min at each table to discuss assigned topics and then will rotate to the next table. Moderator will stay at the designated table. The role of the moderator will be to make sure that all questions are discussed and that the discussion is not taken over by only 1-2 people but that all participants are allowed to express their views. In addition, each moderator will be tasked with summarizing discussions around assigned topics and will present them the third day.

Table 1: discuss topic #1 (moderator #1)

Table 2: discuss topic #2 (moderator #2)

Table 3: discuss topic #3 (moderator #3)

Table 4: discuss topic #4 (moderator #4)

Evening / Social activities
4:00 PM Bus trip to Mount Rushmore
6:30 PM Banquet at Sylvan Lake resort

Saturday, May 25th, 2019 - Reaching a Consensus on Equine Asthma

Morning session - Moderator: Melissa Mazan
08:20 – 08:40 AM Are pertinent biomarkers of equine asthma already available to practitioners/researchers? by Artur Niedźwiedź
08:40 – 09:00 AM How do we standardize immunologic laboratory testing by Eric Richard
9:00 – 9:20 AM Summary of Table 1 discussion topics (Moderator #1)
9:20 – 9:40 AM Summary of Table 2 discussion topics (Moderator #2)
9:40 – 10:00 AM Summary of Table 3 discussion topics (Moderator #3)
10:00 – 10:20 AM Summary of Table 4 discussion topics (Moderator #4)
10:20 – 10:35 AM Break
10:35 – Noon Round table discussion – reach a consensus regarding table topics #1-4 & future directions for equine asthma research
Noon Workshop Adjourns

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