Research from Dr. Chang H. Kim and the Immunology & Hematopoiesis Lab

Cell trafficking and function in the hematolymphoid system

Cell trafficking and function in the hematolymphoid system

We study trafficking mechanisms of lymphocytes for development and effector functions. Special emphasis is on the roles of chemokine receptors and integrins in regulation of the trafficking of various T cell populations (Th17, Th1, Tfh, Tfr, IL-10+ T cells, and FoxP3+ Tregs) and innate lymphoid cells (ILCs).

Mucosal immunity, inflammation, and cancer

Mucosal immunity, inflammation, and cancer

Balanced immunity is important for prevention of inflammation and cancer. We study the interactive relationships among immunity, inflammation and cancer development in the intestine. The cooperative roles of T cells, B cells, dendritic cells and innate lymphoid cells are studied.

Host and microbial metabolites in regulation of the immune system

Host and microbial metabolites in regulation of the immune system

Metabolites produced from dietary factors play important roles in regulation of immunity and inflammation. We study the roles of short-chain fatty acids (SCFAs) and retinoic acid. Short-chain fatty acids are produced by gut commensal bacteria from fermentation of dietary fibers. Retinoic acid is produced from vitamin A. These two different types of metabolites promote immunity and prevent inflammatory responses in the body. In addition, we study the functions of sex hormones and related factors in regulation of immunity and inflammatory processes.

Purdue University College of Veterinary Medicine, 625 Harrison Street, West Lafayette, IN 47907, (765) 494-7607

© 2018 Purdue University | An equal access/equal opportunity university | Copyright Complaints | Maintained by PVM Web Communications

If you have trouble accessing this page because of a disability, please contact PVM Web Communications at vetwebteam@purdue.edu.