Discovery

People

Interests

  • Biocompatibility - Our focus is on biocompatibility issues as they relate to orthopedic implants and devices. At the moment, we study efficacy and safety of resorbable metal.

  • Arthritis - We are interested in macrophage mediated inflammatory arthritis, with an emphasis rheumatoid arthritis and osteoarthritis. The goal of these studies is to develop new diagnostic and therapeutic approaches to these conditions.

  • Canine Gait Analysis - Our immediate goal is to develop and validate Reference Intervals of kinetic and kinematic variables for individual dogs. The Reference Intervals may not only be used for individual clinic patients and research animals in our own gait laboratory, but after validation also may be used as a Reference Intervals in other gait laboratories.

Research Techniques


Studies originating in our laboratory range from clinical studies on naturally occuring disease to cell culture and histopathological studies. Research techniques that we have utilized include radiography, CT-scanning, ultrasound, scintigraphy, DEXA-scanning, MRI, kinetic and kinematic gait analysis, mechanical testing, histopathology, immunocytochemistry, autoradiography, light microscopy, polarization microscopy, transmission electron microscopy, cell culture and flow cytometry.

Collaborations


Most of our investigations are multidisciplinary and involve collaborations from within and outside Purdue University.

Selected Presentations and Publications

Arthritis

  • Novak T, Fites, K, Xu, X, Worke L, Ciesielski A, Breur GJ, Neu C. (2016). In Vivo Cellular Infiltration and Remodeling in a Decellularized Ovine Osteochondral Allograft. Tissue Engineering. Volume 22, Numbers 21 and 22. doi: 10.1089/ten.tea.2016.0149.

  • Hassan EA, Lambrechts NE, Moore GE, Weng HY, Heng HG, Breur GJ. (2015). Development of a model to induce transient synovitis and lameness in the hip joint of dogs. Am J Vet Res. Oct. 76 (10), 869-76. doi:10.2460/ajvr.76.10.869.

  • Vázquez-Portalatín N, Breur GJ, Panitch A, Goergen CJ. (2015). Accuracy of ultrasound-guided intra-articular injections in a guinea pig knees. Bone Joint Res. Jan;4(1):1-5. doi:1302/2046-3758.41.2000370.

  • *Klocke NW, Snyder PW, Widmer RW, Zhong W, McCabe GP, *Breur GJ. Detection of synovial macrophages in the joint capsule of dogs with naturally occurring rupture of the cranial cruciate ligament. Am J Vet Res. 2005;66(3):493-499.

  • *Paulos CM, Turk MJ, Breur GJ, *Low PS. Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. Adv Drug Deliv Rev. 2004;56(8):1205-1217.

  • Turk MJ, Breur GJ, Widmer WR, Paulos CM, Xu L-C, Grote LA, and Low PS. Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis.Arthritis & Rheumatism 2002; 46: 1947-1955.

  • Breur GJ, Widmer WR, Turk MJ, Zody KK, Paulos CM, and Low PS. 99mTc-folate accumulates in canine synovial joints with naturally occurring immune-mediated arthropathy. 48th Annual Meeting of the Orthopaedic Reseach Society. Dallas, TX, 2002.

  • Widmer WR, Breur GJ, Turk MJ, Visco, DM, and Low PS. Use of 99mTc-folate scintigraphy for immune mediated arthropathy. Annual Meeting of the American College of Veterinary Radiology. Chicago, IL, 2000.

  • Johnson J, Austin CC, and Breur GJ. Incidence of canine musculoskeletal disorders in sixteen Veterinary Teaching Hospitals from 1980 through 1989. Veterinary and Comparative Orthopaedics and Traumatology 1994; 7: 56-69.

Gait Analysis

  • Lee CS, Bentley RT, Weng HY, Breur GJ. (2015). A preliminary evaluation of the reliability of a modified functional scoring system for assessing neurologic function in ambulatory thoracolumbar myelopathy dogs. BMC Vet Res. Sep 24;11:241. doi:10.1186/s12917-015-0557-8.

  • Carr, J. G. 2014. "Cut-off Values for Gait Variables to Detect Forelimb Lameness in Individual Dogs." MS Thesis, West Lafayette, IN: Purdue University. 

  • Alshehabat, M.A. 2012. "Instrumented Gait Analysis to Characterize Ataxia in Dogs." West Lafaytte, IN: Purdue University. 

  • Hassan, E. A. 2011. "Clinical and Experimental Studies in the Coxofemoral Joint in Dogs." PhD Thesis, Cairo, Egypt: Cairo University.

  • *Kim J, Kazmierczak KA, *Breur GJ. Comparison of temporospatial and kinetic variables of walking in small and large dogs on a pressure-sensing walkway. Am J Vet Res. 2011;72(9):1171-1177.

  • Misk, T.N. 2010. "Post-Operative Effusion and Inflammation Following Surgical Treatment of Canine Ruptured Cranial Cruciate Ligament." PhD Thesis, Alexandria, Egypt: Alexandria University.

  • Kim, J. 2009. "Gait Analysis as a Measure of Neurological Function in Dogs." PhD, Veterinary Clinical Sciences, United States--Indiana: Purdue University. 

  • *Kim J, Rietdyk S, *Breur GJ. Comparison of two-dimensional and three-dimensional systems for kinematic analysis of the sagittal motion of canine hind limbs during walking. Am J Vet Res. 2008;69(9):1116-1122.

  • *Breur GJ, *Kim J. Should gait analysis be a part of clinical orthopaedic reports? J Small Anim Pract. 2008;49(3):113-114.

  • *Kim J, *Breur GJ. Temporospatial and kinetic characteristics of sheep walking on a pressure sensing walkway. Can J Vet Res. 2008;72(1):50-55.

Congenital and Pediatric Orthopedic Diseases

  • Lavrijsen IC, Leegwater PA, Wangdee C, Van Steenbeek FG, Schwencke M, Breur GJ, Meutstege FJ, Nijman IJ, Cuppen E, Heuven HC, Hazewinkel HA. 2014. "Genome-wide Survey Indicates Involvment of Loci on Canine Chromosomes 7 and 31 in Patellar Luxation in Flat-Coated Retrievers." BMC Genetics 28; 15:64. 

  • Lavrijsen IC, Heuven HC, Breur GJ, Leegwater PA, Meutstege FJ, Hazewinkel HA. Phenotypic and genetic trends of patellar luxation in Dutch Flat-Coated Retrievers. Anim Genet. 2013; 44(6): 736-41.

  • Breur, G.J., N.E. Lambrechts, and R.J. Todhunter. 2012. "The Genetics of Canine Orthopedic Traits." In The Genetics of the Dog, edited by E.A. Ostrander and A. Ruvinsky, 2nd ed., 136-60. Wallingford, UK: CAB International.

  • Towle, H.A., and G.J. Breur. 2012. "Miscellaneous Orthopedic Conditions." In Veterinary Surgery: Small Animal, by K.M. Tobias and SA Johnston, 1st ed., 2:1112-26. St. Louis, MO.: Elsevier Saunders.

  • *Loder RT, *Aronsson DD, Weinstein SL, Breur GJ, Ganz R, Leunig M. Slipped capital femoral epiphysis (Review). Instr Course Lect. 2008;57:473-498.

  • Towle H, Friedlander K, Ko R, Aper R, *Breur G. Surgical treatment of simple syndactylism with secondary deep digital flexor tendon contracture in a Basset Hound. Vet Comp Orthop Traumatol. 2007;20(3):219-223.

  • *Towle HA, Blevins WE, Tuer LR, *Breur GJ. Syndactyly in a litter of cats. J Small Anim Pract. 2007;48(5):292-296.

  • *Aronsson DD, *Loder RT, Breur GJ, Weinstein SL. Slipped capital femoral epiphysis: current concepts. J Am Acad Orthop Surg.2006;14(12):666-679.

  • *Kim J, Blevins WE, *Breur GJ. Morphological and functional evaluation of a dog with dimelia. Vet Comp Orthop Traumatol. 2006;19(4):255-258.

  • *Towle HAM, *Breur GJ. Dysostoses of the canine and feline appendicular skeleton. J Am Vet Med Assoc.2004;225(1):1685-1692.

  • *Werner T, McNicholas WT, Kim J, Baird DK, *Breur GJ. Aplastic articular facets in a dog with intervertebral disk rupture of the 12th to 13th thoracic vertebral space. J Am Anim Hosp Assoc. 2004;40(6):490-494.

  • McNicholas WT, Wilkens BE, Blevins WE, Snyder PW, McCabe GP, Applewhite AA, Laverty PH, and Breur GJ. Spontaneous femoral capital physeal fractures in adult cats: 26 cases (1996–2001). Journal of the American Veterinary Medical Association 2002; 221: 1731-1736.

  • LaFond E, Breur GJ, and Austin CC. Breed susceptibility for developmental orthopedic diseases in dogs. Journal of the American Animal Hospital Association 2002; 38: 467-477.

  • Breur GJ, Allen MJ, Carlson SJ, and Richardson DC. Markers of bone metabolism in growing Labrador Retrievers. 36th Annual Scientific Meeting of the American College of Veterinary Surgeons. Chicago, IL, 2001.

  • Breur, G.J., G. Lust, and R.J. Todhunter. 2001. "Genetics of Canine Hip Dysplasia and Other Orthopedic Traits." The Genetics of the Dog, by A. Ruvinsky and J. Sampson, 267-98. Wallingford, UK: CAB International.

  • Munjar TA, Austin CC, and Breur GJ. Comparison of risk factors for hypertrophic osteodystrophy, craniomandibular osteopathy and canine distemper virus infection. Veterinary and Comparative Orthopaedics and Traumatology 1998; 11: 37-43.

  • Breur GJ, Lapierre MD, Stechuchak KM, and McCabe GP. The domain of hypertrophic chondrocytes in growth plates growing at different rates.Calcified Tissue International 1997; 61: 418-425.

  • Breur GJ, Turgai J, VanEnkevort BA, Farnum CE, and Wilsman NJ. A stereological and serial section analysis of chondrocytic enlargement in the proximal tibial growth plate of the rat. Anatomical Record 1994; 239: 255-268.

  • Breur GJ, Farnum CE, Padgett GA, and Wilsman NJ. Cellular basis of decreased rate of longitudinal growth of bone in pseudoachondroplastic dogs. Journal of Bone and Joint Surgery 1992; 74A: 516-528.

  • Breur GJ, VanEnkevort BA, Farnum CE, and Wilsman NJ. Linear relationship between the volume of hypertrophic chondrocytes and the rate of longitudinal bone growth in growth plates. Journal of Orthopaedic Research 1991; 9: 348-359.

Biocompatibility

  • Duffy DJ, Main RP, Moore GE, Breur GJ, Millard RP. (2015). Ex vivo biomechanical comparison of barbed suture and standard polypropylene suture for acute tendon laceration in a canine model. Vet Comp Orthop Traumatol. 28(4):263-9. doi:10.3415/VCOT-14-11-0174.

  • Dickerson DA, Misk TN, Van Sickle DC, Breur GJ, Nauman EA. In vitro and in vivo evaluation of orthopedic interface repair using a tissue scaffold with a continuous hard tissue-soft tissue transition. J Orthop Surg Res. 2013; 8: 18.

  • Kishore V, Uquillas JA, Dubikovsky A, Alshehabat MA, Snyder PW, Breur GJ, Akkus O. In vivo response to electrochemically aligned collagen bioscaffolds. J Biomed Mater Res B Appl Biomater. 2012;100B(2):400-408.

  • Nicholson GP, *Breur GJ, *Van Sickle D, Yao JQ, Kim J, Blanchard CR. Evaluation of a cross-linked acellular porcine dermal patch for rotator cuff repair augmentation in an ovine model. J Shoulder Elbow Surg. 2007;16(5 Suppl):S184-190. Epub 2007 Jun 15.

  • *Laverty PH, *Leskovar A, *Breur GJ, *Coates JR, Bergman RL, *Widmer WR, *Toombs JP, Shapiro S, *Borgens RB. A preliminary study of intravenous surfactants in paraplegic dogs: polymer therapy in canine clinical SCI. J Neurotrauma. 2004;21(12):1767-1777.

  • Ladlow JF, Hoffman WE, Breur GJ, Richardson DC, and Allen MJ. Biological variability in serum and urinary indices of bone formation and resorption in dogs. Calcified Tissue International 2002; 70: 186-193.

  • Allen MJ, Allen LCV, Hoffmann WE, Richardson DC, and Breur GJ. Urinary markers of type I collagen degradation in dogs. Research in Veterinary Science 2000; 69: 123-127.

  • Allen LCV, Allen MJ, Breur GJ, Hoffmann WE, and Richardson DC. A comparison of two techniques for the determination of serum bone-specific alkaline phosphatase activity in dogs. Research in Veterinary Science 2000; 68: 231-235.

  • Carlson SJ, Allen MJ, Lalor PA, Snyder PW, Aberman HM, and Breur GJ. Biochemical markers of bone metabolism in a stable model of early periprosthetic osteolysis. 46th Annual Meeting of the Orthopaedic Research Society. Orlando, FL, 2000.

  • Breur GJ, Aberman HM, Snyder PW, Toombs JP, Blevins WE, and Lalor PA. PMMA particles in a stable canine model of aseptic implant loosening. 45th Annual Meeting of the Orthopaedic Research Society. San Diego, CA, 1999.

  • Allen MJ, Breur GJ, Hoffmann WE, and Richardson DC. Serum markers of bone metabolism in the dog. American Journal of VeterinaryResearch 1998; 59: 250-254.

  • Lalor PA, Breur GJ, Snyder PW, Toombs JP, Blevins WE, and Aberman HM. Early osteolysis in a stable canine model of aseptic implant loosening. 44th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA, 1998.

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