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Scott Crist, PhD

  • Department of Comparative Pathobiology
  • Research Assistant Professor
  • Purdue University College of Veterinary Medicine
  • 625 Harrison Street
  • West Lafayette, IN 47907



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Education

  • 1997 - PhD | University of Kentucky
  • 1990 - BS | University of Iowa

Experience

  • 2007 - | Assistant Research Professor, Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana.
  • 2007 - | Assistant Research Professor, Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana.
  • 2004 - 2007 | Associate Research Scientist, Department of Urology, University of Iowa, Iowa City, Iowa
  • 2004 - | Associate Research Scientist, Principle Investigator of a NIH-funded project Department of Urology, University of Iowa, Iowa City, Iowa
  • 2003 - 2004 | Research Investigator, (Supervisor: Dr. Timothy Ratliff) Department of Urology, University of Iowa, Iowa City, Iowa
  • 2002 - 2004 | Research Investigator, Department of Urology, University of Iowa. Iowa City, Iowa.
  • 2000 - 2000 | Discussion Group proctor, Medical Immunology College of Medicine, University of Iowa, Iowa City, Iowa
  • 1999 - 1999 | Discussion Group proctor, Medical Immunology, College of Medicine, University of Iowa, Iowa City, Iowa
  • 1999 - 2002 | Research Fellow, Department of Urology, University of Iowa, Iowa City, Iowa Advisor: Tim Ratliff, Ph.D.
  • 1999 - 2003 | Research Fellow, (Supervisor: Dr. Timothy Ratliff) Department of Urology, University of Iowa, Iowa City, Iowa
  • 1997 - 1999 | Research Fellow, (Supervisor: Dr. William See) Department of Urology, University of Iowa, Iowa City, Iowa
  • 1997 - 1999 | Research Fellow, Department of Urology, University of Iowa. Advisor: William See, M.D.
  • 1995 - 1995 | Teaching Assistant as a Doctoral Candidate in the Department of Microbiology and Immunology, University of Kentucky. Coordinator: Robert Perry, Ph.D. Medical Microbiology. Assisted in the instruction (laboratory and lecture) of 2nd year medical students i
  • 1992 - 1997 | Teaching/Research Assistant, Doctoral candidate, Department of Microbiology and Immunology, University of Kentucky, Lexington, Kentucky
  • 1992 - 1997 | Research Assistant as a Doctoral Candidate in the Department of Microbiology and Immunology, University of Kentucky. Advisor: Vivek Rangnekar, Ph.D.
  • 1989 - 1992 | Laboratory Technician, Department of Urology, University of Iowa Hospitals & Clinics, Iowa City, Iowa. Supervisor: William See, MD.
  • 1989 - 1992 | Laboratory Technician, Department of Urology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
  • 1988 - 1989 | Undergraduate work-study, University of Iowa, Department of Microbiology, Supervisor: David Lubaroff, Ph.D. and Department of Urology, Supervisor: William See, MD
  • 1986 - 1989 | Floor Nurse, part-time, Departments of Orthopedics, Dermatology, Urology, and Neurosurgery. University of Iowa Hospitals and Clinics, Iowa City, Iowa
  • 1986 - 1988 | Undergraduate work-study, University of Iowa, Department of Microbiology, Supervisor: Thomas Feldbush, Ph.D.
  • 1985 - 1986 | Private Tutor, Kirkwood Community College, Department of Math and Sciences

Selected Publications

  • Crist SA, Sprague DB, and Timothy L. Ratliff. Retinoids are potent inducers of CD154 in megakaryocytes. (In preparation)
  • Crist SA, Sprague DB, and Timothy L. Ratliff. CD154 expression in megakaryocytes is dependent on a functional Ets-1 element proximal to the transcription start site. (In preparation)
  • Crist SA, Sprague DB, and Timothy L. Ratliff. CD154 Expression and Regulation in Megakaryocytes and Platelets. (Resubmitted as a revived manuscript to Blood Journal)
  • Scott A. Crist, Bennett D. Elzey, Jeffery Stakk, Haley W. Sinn, Steven Lentz, and Timothy L. Ratliff. Regulation of Fas ligand expression in megakaryocytes. (Submitted)
  • Crist SA, Sprague, DB, Griffith TS, Staack JB, Ratliff TL. Transcriptional regulation of TNF-related apoptosis-inducing ligand (TRAIL) in megakaryocytes. (Resubmitted to Exp Hematol as a revised manuscript).
  • Crist SA, Elzey BD, Ludwig AT, Griffith TS, Staack JB, Lentz SR, Ratliff TL. Expression of TNFrelated apoptosis-inducing ligand (TRAIL) in megakaryocytes and platelets. Exp Hematol. 2004 Nov;32(11):1073-81.
  • Crist SA, Griffith TS, Ratliff TL. Structure/function analysis of the murine CD95L promoter reveals the identification of a novel transcriptional repressor and functional CD28 response element. J Biol Chem. 2003 Sep 19;278(38):35950-8.
  • Siemens DR, Crist S, Austin JC, Tartaglia J, Ratliff TL. Comparison of viral vectors: gene transfer efficiency and tissue specificity in a bladder cancer model. J Urol. 2003 Sep;170(3):979-84.
  • Chen F. H., Crist, S. A., Zhang, G. J., Iwamoto, Y. and W. A. See. Interleukin-6 production by human bladder tumor cell lines is up-regulated by bacillus Calmette-Guerin through nuclear factor-kappaB and Ap-1 via an immediate early pathway. J Urol. 168:78
  • Zhang, Guang-Jian, Crist, Scott A., McKerrow, Amy, Ladehoff, David, and William A. See. Autocrine Interleukin-6 Production by Human Transitional Carcinoma Cell Lines Upregulate Expression of the a5b1 Fibronectin Receptor. J Urol. 163:1553-9, 2000
  • Muthukkumar, S., Sells, S.F., Crist, S.A., Rangnekar, V.M. Interleukin-1 induces growth arrest by hypophosphorylation of the retinoblastoma gene product, Rb. J. Biol. Chem. 271:5733-5740, 1996
  • Sells, S.F., Muthukkumar, S., Sukhatme, V.P., Crist, S.A., Rangnekar, V.M. The zinc finger transcription factor EGR-1 impedes interleukin-1 inducible tumor growth arrest. Mol. Cell. Biol. 15:682- 692, 1995
  • Sells, S.F., Wood, D.P., Jr., Joshi-Barve, S.S., Muthukkumar, S., Jacob, R.J., Crist, S.A., Humphreys, S., Rangnekar, V.M. Commonality of the Gene Programs Induced by Effectors of Apoptosis in Androgendependent and -independent Prostate Cells. Cell Growth
  • See, W.A., Yong, X., Crist, S.A., Hedicen, S. Diversity and modulation of plasminogen activator for activity in human transitional carcinoma cell lines. J. Urol..151:1691-1696, 1994.
  • See, W.A., Rohlf, D.P., Crist, S.A. In vitro particulate adherence to fibronectin: correlation with in vivo particulate adherence to sites of bladder injury. J. Urol. 147:1416-1423. 1993
  • See, W.A., Crist, S.A., Williams, R.D. Single-dose preoperative systemic cyclophosphamide for the prevention of bladder tumor implantation in F-344 rats: site of drug activity. Cancer Res. 51:1378-1383,1991.
  • See, W.A., Crist, S.A., Boileau, M.A., Williams, R.D. Single-dose preoperative systemic cyclophosphamide for the prevention of bladder tumor implantation in F-344 rats. Cancer Res. 51:1373-1377, 1991.