CPB 697 RESEARCH SEMINAR

DEPARTMENT OF COMPARATIVE PATHOBIOLOGY

Tracy H. Vemulapalli, DVM, MS

Graduate Student in Laboratory Animal Medicine

Purdue University

“Evaluation Of The Effect Of Rounded-tip And Catheter Lock Solution On Patency

And Tissue Reactivity Of Indwelling Jugular Catheters In Rats”

Thursday, November 15, 2007

VPTH 112

3:30 p.m.

ABSTRACT:

Many research protocols require continuous or long-term vascular access for blood sample collection and/or infusion. This study describes findings of patency and biocompatability of Sprague Dawley rats surgically modified with both blunt- and rounded-tip jugular vein catheters. Lock solutions compared include glycerol with 500 units/ml heparin (using 1000 U/ml stock solution), glycerol with 500 units/ml heparin (using 10,000 U/ml stock solution), and taurolidine-citrate. Catheters were evaluated for patency, culture of blood and catheter tip, as well as vascular tissue reactivity of the rats.