CPB 697 RESEARCH SEMINAR
Chuanwu Wang, Bachelor of Agronomy in Veterinary Medicine,
Master of Agronomy in Veterinary Medicine
Graduate Student in Immunology
“Trafficking Receptors And In vivo
Migration Of Th17 Cells
Versus FoxP3+ Regulatory T Cells”
Thursday, November 15, 2007
VPTH 112
3:30 p.m.
ABSTRACT:
The immune system is regulated by various T cell subsets. Among them, interleukin-17-producing T cells (Th17 cells) play important roles in the pathogenesis of autoimmune diseases and, perhaps, host defense against pathogens. FoxP3+ T cells, on the other hand, play important roles in suppressing autoimmune diseases and inflammation. The trafficking receptors important for in vivo migration of Th17 cells and FoxP3+ T cells remain poorly elucidated. We systematically investigated the trafficking receptors expressed by Th17 cells and FoxP3+ T cells. We also examined the in vivo homing behavior of the two T cell subsets. We identified major trafficking receptors of Th17 cells and investigated the regulation mechanisms of the receptor expression. We found that Th17 cells and FoxP3+ T cells are distinct in migration in vivo and regulation of the trafficking receptors. These results provide insights into in vivo distribution of the two important T cell subsets and regulation of immune responses.