CPB 697 RESEARCH SEMINAR
Jee Ho Lee, MS
Graduate Student in Immunology
Department of
“Role of FoxP3+CD4+
cells in Suppression of Extramedullary Hematopoiesis”
Thursday, November 8, 2006
VPTH 112 - 3:30
p.m.
ABSTRACT:
Hematopoiesis is largely limited to the medulla of bone marrow in mammals but extramedullary hematopoiesis can occur in other organs such as spleen and diseased tissue sites. FoxP3+ regulatory T cells play important roles in regulation of hyperimmune responses and inflammatory diseases. However, the role of these T cells in regulation of hematopoiesis is unknown. I will present data suggesting a novel role of FoxP3+ T cells in regulation of extramedullary hematopoiesis. I will also present a possible mechanism with which FoxP3+ T cells regulate the extramedullary hematopoiesis. I will conclude the talk by discussing the biological significance of the function of FoxP3+ regulatory T cells.