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Harm HogenEsch, DVM, Ph.D.
Diplomat, A.C.V.P.


Department Head and Professor of Immunopathology
School of Veterinary Medicine
Purdue University
West Lafayette, IN 47907
Phone: 765-494-0596
Email: hogenesch@purdue.edu

 Image of Dr. HogenEsch

Education

Institution Field Degree Year
University of Utrecht, Netherlands. Veterinary Medicine D.V.M. 1984
University of Illinois, Urbana, IL. Pathology and Immunology Ph.D. 1989

Professional Experience

1985-1989 Teaching Assistant in Anatomical Pathology, Department of Veterinary Pathobiology, University of Illinois, Urbana, IL.
1989-1993 Pathologist, Institute for Ageing and Vascular Research, TNO, Leiden, the Netherlands.
1993-1994 Visiting Assistant Professor of Immunopathology, Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN.
1994-1997 Assistant Professor of Immunopathology, Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN.
1997-2001 Associate Professor of Immunopathology, Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN.
2001-present Professor of Immunopathology, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN.
2001-present Head, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN.

Awards and Honors

1982 Award from the Dutch government for excellence in academic study
1984 Doctor of Veterinary Medicine cum laude from University of Utrecht
1988 Phi Kappa Phi (honor society)
1988 Phi Zeta (veterinary honor society)
1988 C.L. Davis Scholarship in Veterinary Pathology
1989 Diplomate, American College of Veterinary Pathologists
1997 Outstanding Paper in the Agricultural and Veterinary Field (Controlled Release Society)
1999 Pfizer Award for Research Excellence
2003 Society for Comparative Endocrinology Award for excellence in the advancement of knowledge concerning small animal endocrinology

Overview of Research

Immunopathology
    Vaccine development, adjuvants, and vaccine safety; Immunopathology of allergic disease.

Publications

Refereed journals

1. HogenEsch H, Whiteley HE, Vicini DS and Helper LC (1987) Seminoma with metastases in the eyes and the brain in a dog. Vet Pathol 24:278-280.

2. HogenEsch H, Housman JM and Felsburg PJ (1987) Canine Peyer's patches: Macroscopic, light microscopic, scanning electron microscopic and immuno-histochemical investigations. Adv Exp Biol Med 216:249-256.

3. Felsburg PJ, Glickman LT, Shofer F, Kirkpatrick CE and HogenEsch H (1987) Clinical, Immunologic and epidemiologic characterization of canine selective IgA deficiency. Adv Exp Biol Med 216:1461-1470.

4. HogenEsch H and Felsburg PJ (1989) Development and functional characterization of T cell lines from canine Peyer's patches. Vet Immunol Immunopathol 23:29-39.

5. HogenEsch H and Felsburg PJ (1990) Ultrastructure and alkaline phosphatase histochemistry of the dome epithelium of canine Peyer's patches. Vet Immunol Immunopathol 24:177-186.

6. DeBruin RWF, HogenEsch H, Heineman E, Jeekel J and Marquet RL (1991) Fulminant graft-versus-host disease after FK-506 treatment in fully-allogeneic small bowel transplantation. Transpl Proc 23:3257-3259.

7. HogenEsch H and Felsburg PJ (1992) Immunohistology of Peyer's patches in the dog. Vet Immunol Immunopathol 30:147-160.

8. HogenEsch H and Felsburg PJ (1992) Isolation and characterization of cells from canine Peyer's patches: Surface phenotype and in vitro immunoglobulin secretion. Vet Immunol Immunopathol 31: 1-10.

9. HogenEsch H, Broerse JJ and Zurcher C (1992) Neurohypophyseal Astrocytoma (pituicytoma) in a Rhesus monkey (Macaca Mulatta). Vet Pathol, 29:359-361.

10. DeGeus B, HogenEsch H, Kubo RT and Rozing J (1992) Unusual glycosylphosphatidylinositol anchored membrane protein expression on intestinal intraepithelial lymphocytes. Int Immunol, 4:899-903.

11. Felsburg PJ, HogenEsch H, Somberg RL, Snyder PW, Glickman LT (1992) Immunologic abnormalities in canine juvenile polyarteritis syndrome: A naturally occurring animal model of Kawasaki disease. Clin Immunol Immunopathol 65:110-118.

12. HogenEsch H, De Geus B, Tielen F, Rozing J (1993). Constitutive expression of Ly-6.A2 on murine keratinocytes and inducible expression on TCRγδ+ dendritic epidermal T cells. J Dermatol Sci, 5:114-121.

13. HogenEsch H, Niewold ThA, Higuchi K, Tooten PCA, Gruys E and Radl J (1993) Senile gastrointestinal and secondary amyloidosis in aged C57BL/Ka mice. Effect of long-term immunosuppression. Virchows Arch B. Cell Pathol, 64:37-43.

14. HogenEsch H, Gijbels MJJ, Offerman E, Van Hooft J, Van Bekkum DW, Zurcher, C (1993) A spontaneous mutation characterized by chronic proliferative dermatitis (cpd) in C57BL/Ka mice. Am J Pathol, 143:972-982.

15. De Geus B, HogenEsch H, de Heer E, Bruijn JA, Van den Enden M, Rozing J (1993) Effect of chronic graft-versus-host disease on the intestine of adult BDF1 mice. Int J Exp Pathol, 74:371-377.

16. Van Vlijmen BJM, Van den Maagdenberg AMJM, Gijbels MJJ, De Bruijn IH, Van der Boom H, HogenEsch H, Frants RR, Hofker MH, Havekes LM (1994) Diet-induced hyperlipoproteinemia and atherosclerosis in transgenic APOE3-Leiden mice. J Clin Invest, 93:1403-1410.

17. Wolvekamp MCJ, de Bruin RWF, HogenEsch H, Marquet RL, Heineman E (1994). Serum diamine oxidase has no prognostic value in acute small bowel rejection in rats. Transpl Proc, 26:1564-1566.

18. Bowersock TL, HogenEsch, Suckow M, Davis-Snyder E, Borie D, Park H, Park K (1994). Oral administration of mice with ovalbumin encapsulated in alginate microspheres. Polymer Preprints 35: 405-406.

19. Gijbels MJJ, HogenEsch H, Blauw B, Roholl P, Zurcher C (1995) Ultrastructure of the epidermis of mice with chronic proliferative dermatitis (cpd). Ultrastruct Pathol, 19:107-111.

20. Snyder PW, Kazacos EA, Scott-Moncrieff JC, HogenEsch H, Carlton WW, Glickman LT and Felsburg PJ (1995) Pathologic features of naturally occurring juvenile polyarteritis in beagle dogs. Vet Pathol, 32:337-345.

21. Gijbels MJJ, Bruijnzeel PLB, Toonstra J, Eliott, GR, Zurcher C, HogenEsch H (1995) Chronic proliferative dermatitis. Comp Pathol Bull, 27 (2):2-3.

22. HogenEsch H, Snyder PW, Scott-Moncrieff JC, Glickman LT, Felsburg PJ (1995). Serum IL-6 activity in dogs with juvenile polyarteritis syndrome: Effect of corticosteroids. Clin Immunol Immunopathol, 77:107-110.

23. Gijbels MJJ, HogenEsch H, Bruijnzeel PLB, Elliott G, Zurcher C (1995). Maintenance of donor phenotype after full-thickness transplantation from mice with chronic proliferative dermatitis (cpdm/cpdm) to C57BL/Ka and nude mice and vice versa. J Invest Dermatol, 105:769-773.

24. Gallardo Torres HI, Gijbels MJJ, HogenEsch H, Kraal G (1995) Chronic proliferative dermatitis in mice. Neutrophil-endothelium interactions and the role of adhesion molecules. Pathobiology, 63:341-347.

25. Rundell A, HogenEsch H, DeCarlo R (1995) Enhanced modeling of the immune system to incorporate memory and natural killer cell activity. Proc. Am. Control Conf., 95CH35736, 255-259.

26. Gijbels MJJ, Zurcher C, Kraal G, Elliott G, HogenEsch H, Schijff G, Savelkoul H, Bruijnzeel PLB (1996) Pathogenesis of skin lesions in mice with chronic proliferative dermatitis (cpdm/cpdm). Am J Pathol, 148:941-950.

27. Radl J, Van Arkel C, Hopstaken CM, HogenEsch H (1996) Ten fold increased incidence of spontaneous multiple myeloma in long-term immunosuppressed aging C57BL/KaLwRij mice. Clin Immunol Immunopathol,79:155-162.

28. HogenEsch H, Torregrosa S, Borie D, Gaskell , Bowersock TL (1996) Systemic and pulmonary immune response to intrabronchial administration of ovalbumin in calves. Vet Immunol Immunopathol, 51:293-302.

29. Bowersock TL, HogenEsch H, Suckow M, Porter R, Jackson R, Park H, Park K (1996) Oral vaccination hydrogel systems. J Control Rel, 39:209-220.

30. Guptill L, Slater L, Wu CC, Lin TL, Welch DF, Glickman LT, HogenEsch H (1997) Experimental infection of young specific pathogen free cats with Bartonella henselae. J Inf Dis, 176:206-216.

31. Rundell A, DeCarlo R, Balakrishnan V, HogenEsch H (1997). Investigations into treatment strategies aiding the immune response to Haemophilus influenzae. Proc. Am. Control Conf., 97CH36041, 208-212.

32. HogenEsch H, Hahn FF (1998). Primary vascular neoplasms of lymph nodes of aging dogs. Vet Pathol, 35: 74-76.

33. Bowersock TL, HogenEsch H, Wang B, Torregrosa S, Ryker D, Park H, Blevins B, Park K (1998) Oral administration of alginate microspheres stimulates pulmonary immunity in cattle. Immunology Letters, 60: 37-43.

34. Rundell A, DeCarlo R, Balakrishnan V, HogenEsch H (1998) Systematic method for determining drug treatment strategies aiding the humoral immune response. IEEE Trans on Biomed Engineering, 45: 429-439.

35. Bowersock TL, HogenEsch H, Wang B, Torregrosa S, Borie DL, Park H, Park K (1998) Induction of pulmonary immunity in cattle by oral administration of antigen encapsulated in alginate microspheres. STP Pharma Sciences, 8:53-57.

36. Jarvinen L, HogenEsch H, Suckow MA, Bowersock TL (1998) Induction of protective immunity in rabbits by coadministration of inactivated Pasteurella multocida toxin and potassium thiocyanate extract. Infect Immun, 66:3788-3795.

37. Guptill L, Slater, LN, Wu CC, Lin T-L, Glickman LT, Welch DF, Tobolski J, HogenEsch H (1998) Evidence of reproductive failure and lack of perinatal transmission of Bartonella henselae in experimentally infected cats. Vet Immunol Immunopathol, 65:177-189.

38. Rundell A, DeCarlo R, HogenEsch H, Doerschuk P (1998) The humoral immune response to Haemophilus influenzae type b: A mathematical model based on T-zone and germinal center B-cell dynamics. J Theor Biol, 194:341-381.

39. HogenEsch H, Boggess D, Sundberg JP (1999). Changes in keratin and filaggrin expression in the skin of chronic proliferative dermatitis mutant mice (cpdm). Pathobiology, 67:45-50.

40. HogenEsch H, Azcona-Olivera J, Scott-Moncrieff C, Snyder PW, Glickman LT (1999) Vaccine-induced autoimmunity in the dog. Adv Vet Sci, 41: 733-747.

41. Mohammad T, Morrison H, HogenEsch H (1999) Urocanic acid photochemistry and photobiology. Photochem Photobiol, 69:115-135.

42. Bowersock TL, HogenEsch H, Suckow MA, Guimond P, Martin S, Borie D, Torregrosa S, Park H, Park K (1999) Oral vaccination of animals with antigens encapsulated in alginate microspheres. Vaccine 17:1804-1811.

43. HogenEsch H, Janke S, Boggess D, Sundberg JP (1999) Absence of Peyer’s patches and abnormal lymphoid microarchitecture in chronic proliferative dermatitis (cpdm/cpdm) mice. J Immunol, 162:3890-3896.

44. Aggarwal N, HogenEsch H, Guo PX, North A, Suckow M, Mittal SK (1999)Biodegradable alginate microspheres as a delivery system for naked DNA. Can J Vet Res 63:148-152.

45. Guptill L, Slater L, Wu CC, Glickman L, Lin, TL, Welch D Tobolski J, HogenEsch H(1999) Experimental infection of neonatal specific pathogen free cats with Bartonella henselae. Vet Immunol Immunopathol, 71:233-244.

46. Rebelatto MC, Mead C, HogenEsch H (2000) Lymphocyte populations and adhesion molecule expression in bovine tonsils. Vet Immunol Immunopathol, 73:15-29.

47. Jarvinen LZ, HogenEsch H, Suckow MA, Bowersock TL (2000) Intranasal vaccination of New Zealand White rabbits against pasteurellosis using alginate-encapsulated Pasteurella multocida toxin and potassium thiocyanate extract. Comparative Medicine, 50:263-269.
48. Hartnett BJ, Somberg RJ, Krakowka S, Ochs HD, HogenEsch H, Moore PF, Weinberg KI, Felsburg PJ (2000). B cell function in canine X-linked severe combined immunodeficiency. Vet Immunol Immunopathol, 75:121-134.
49. Moffatt S, Hays J, HogenEsch H, Mittal SK (2000) Circumvention of vector-specific neutralizing antibody response by alternating use of human and non-human adenoviruses: Implications for gene therapy. Virology, 272:159-167.
50. Barton D, HogenEsch H, Weih F (2000) RelB-deficient mice develop skin lesions similar to atopic dermatitis. Eur J Immunol, 30: 2323-2332.
51. Guptill L, Wu CC, Glickman L, Turek J, Slater L, HogenEsch H (2000) Extracellular Bartonella henselae and artifactual intraerythrocytic pseudoinclusions in experimentally infected cats. Vet Microbiol, 76:283-290.
52. Mittal SK, Aggarwal N, Sailala G, Van Olphen A, HogenEsch H, North A, Hays J, Moffatt S (2000) Immunization with DNA, adenovirus or both in biodegradable alginate microspheres: Effect of route of inoculation on immune response. Vaccine, 19:253-263.
53. Sundberg JP, Boggess D, Shultz LD, Fijneman RJA, Demant P, HogenEsch H, Cox GA (2000) The chronic proliferative dermatitis mouse mutation (cpdm): Mapping of the mutant gene locus. J Exp Anim Sci, 41:101-108.
54. Gijbels MJJ, Elliott GR, HogenEsch H, Zurcher C, van den Hoven A, Bruijnzeel PLB (2000) Therapeutic interventions in mice with chronic proliferative dermatitis (cpdm/cpdm). Exp Dermatol , 9:351-358.
55. Rudmann DG, Moore MW, Tepper JS, Aldrich MC, Pfeiffer JW, HogenEsch H, Tumas DB (2000) Modulation of allergic inflammation in mice deficient in TNF receptors. Am J Physiol (Lung Cell Mol Physiol), 279: L1047-1057.
56. Shi Y, HogenEsch H, Regnier F, Hem SL (2001) Detoxification of endotoxin by aluminium-containing adjuvants. Vaccine, 19:1747-1752.
57. HogenEsch H, Torregrosa SE, Boggess D, Sundberg BA, Carroll J, Sundberg JP (2001) Increased expression of type 2 cytokines in chronic proliferative dermatitis (cpdm) mutant mice and resolution of inflammation following treatment with IL-12. Eur J Immunol, 31:734-742.
58. Chang M-F, Shi Y, Nail SL, HogenEsch H, Adams SB, White JL, Hem SL (2001) Degree of antigen adsorption in the vaccine or interstitial fluid and its effect on on the antibody response in rabbits. Vaccine, 19:2884-2889.
59. Rebelatto MC, Siger L, HogenEsch H (2001) Kinetics and type of immune response following intranasal and subcutaneous immunisation of calves. Res Vet Sci, 71:1-15.
60. Shi Y, HogenEsch H, Hem SL (2001) Change in the degree of adsorption of proteins by aluminum-containing adjuvants following exposure to interstitial fluid: Freshly prepared and aged model vaccines. Vaccine, 20:80-85.
61. Rebelatto MC, Guimond P, Bowersock TL HogenEsch H (2001) Induction of systemic and mucosal immune response in cattle by intranasal administration of pig serum albumin in alginate microspheres. Vet Immunol Immunopathol, 83:93-105.
62. HogenEsch H, Dunham AD, Scott-Moncrieff C, Glickman LT, DeBoer D (2002) Induction of total and antigen-specific IgE by rabies vaccine in dogs. Am J Vet Res, 63:611-616.
63. HogenEsch H (2002) Mechanisms of stimulation of the immune response by aluminum adjuvants. Vaccine, 20:S34 - S39.
64. Scott-Moncrieff J, Azcona-Olivera J, Glickman NW, Glickman LT, HogenEsch H (2002) Evaluation of antithyroglobulin antibodies in pet and laboratory dogs after routine vaccination. JAVMA, 221:515-521.
65. Suckow MA, Rebelatto MC, Schulman A, HogenEsch H (2002) Sebaceous adenocarcinoma of the external auditory canal in a New Zealand white rabbit. J Comp Pathol, 127:301-3..
66. Sailaja G, HogenEsch H, North A, Hays J, Mittal SK (2002) Encapsulation of recombinant adenovirus into alginate microspheres circumvents vector-specific immune response. Gene Therapy, 9:1722-9.
67. Kidane A, Guimond P, Ju TR, Sanchez M, Gibson J, North A, HogenEsch H, Bowersock TL (2002) The effects of cellulose derivatives and poly (ethylene oxide)-poly(propylene oxide) triblock copolymers (Pluronic® surfactants) on the properties of alginate based microspheres and their interactions with phagocytic cells. J Control Rel, 85: 181-189.
68. Suckow MA, Jarvinen LZ, HogenEsch H, Park K, Bowersock TL (2002). Immunization of rabbits against a bacterial pathogen with an alginate microparticle vaccine. J Control Rel, 85:227-235.
69. Iyer S, HogenEsch H, Hem SL (2003) Effect of the degree of phosphate substitution in aluminum hydroxide adjuvant on the adsorption of phosphorylated proteins. Pharm Dev Tech, 8:81-86.
70. Iyer S, HogenEsch H, Hem SL (2003) Relationship between the degree of antigen adsorption to aluminum hydroxide adjuvant in interstitial fluid and antibody production. Vaccine, 21:1219-1223.
71. Danczyk R, Krieder B, North A, Webster T, HogenEsch H, Rundell A (2003) Comparison of antibody functionality using different immobilization methods. Biotechnol Bioeng; 84:215-23.
72. HogenEsch H, Thompson S, Dunham A, Ceddia M, Hayek M (2004) Effect of age on immune parameters and the immune response of dogs to vaccines: A cross-sectional study. Vet Immunol Immunopathol, 97:77-85.
73. Guptill L, Wu CC, HogenEsch H, Slater L, Glickman N, Dunham A, Syme H, Glickman LT (2004) Prevalence, risk factors, and genetic diversity of Bartonella henselae infections in pet cats in four regions of the United States. J Clin Microbiol, 42:652-659.
74. Iyer S, Robinett RSR, HogenEsch H, Hem SL (2004) Mechanism of adsorption of hepatitis B surface antigen by aluminum hydroxide adjuvant. Vaccine, 22:1475-1479.
75. Morefield GL, HogenEsch H, Robinson JP, Hem SL (2004) Distribution of adsorbed antigen in mono-valent and combination vaccines. Vaccine, 22:1973-1984.
76. Sundberg JP, Haschek-Hock WM, Hackman RC, HogenEsch H (2004) Developing a comprehensive mouse pathology program. Comp Med, 54:615-619.
77. HogenEsch H (2004). Chemokines and chemokine receptors in allergic inflammation – Human disease and mouse models. Curr Med Chem – Anti-Inflammatory and Anti-Allergy Agents, 3:351-361.
78. Orian-Rousseau V, Mink S, Mengwasser J, HogenEsch H, Guo F, Thies W, Hofman M, Herrlich P, Ponta H (2005) Genes upregulated in a metastasizing human colon carcinoma cell line. Int J Cancer, 113:699-705.
79. Morefield G, Jiang D, Romero-Mendez IZ, Geahlen RL, HogenEsch H, Hem SL (2005) Effect of phosphorylation of ovalbumin on adsorption by aluminum-containing adjuvants and elution upon exposure to interstitial fluid. Vaccine, 23:1502-1506.
80. Morefield GL, Sokolovska A, Jiang D, HogenEsch H, Robinson JP, Hem SL (2005) Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro. Vaccine, 23: 1588-95.
81. Renninger ML, North A, Boggess D, Sundberg JP, HogenEsch H (2005) Increased chemokine expression in the skin of chronic proliferative dermatitis (cpdm/cpdm) mice. Exp Dermatol, 14:906-913.
82. Kiupel M, Stevenson GW, Galbreath EJ, North A, HogenEsch H, Mittal SK (2005) Porcine Circovirus type 2 (PCV2) causes apoptosis in experimentally inoculated BALB/c mice. BMC Veterinary Research, 1:7.
83.Sanakkayala N, Sokolovska A, Gulani J, HogenEsch H, Sriranganathan N, Boyle SM, Schurig GG, Vemulapalli R. (2005) Induction of heterologous antigen-specific Th1 type immune response by gamma-iradiated recombinant Brucella abortus RB51. Clin Diagn Lab Immunol, 12:1429-36.
84. Gupta SK , Fitzgerald JF , Kondratyuk T ,Hogenesch H (2006) Cytokine expression in normal and inflamed esophageal mucosa: A study into the pathogenesis of allergic eosinophilic esophagitis. J Pediatr Gastroenterol Nutr , 42:22-26.
85. Jiang D, Morefield GL, HogenEsch H, Hem SL (2006) Relationship of adsorption mechanism of antigens by aluminum-containing adjuvants to in vitro elution in interstitial fluid. Vaccine, 24:1665-1669.
86. Seymour R, Sundberg JP, HogenEsch H (2006) The pathology of lymphoid organs in immunodeficient mutant mice. Vet Pathol, 43:401-423.
87. Scott-Moncrieff JC, Glickman NW, Glickman LT, HogenEsch H (2006) Lack of association between repeated vaccination and thyroiditis in laboratory beagles. J Vet Int Med, 20:818-822.
88. HogenEsch H, Dunham A, Seymour R, Renninger ML, Sundberg JP (2006) Expression of chitinase-like proteins in the skin of chronic proliferative dermatitis (cpdm/cpdm) mice. Exp Dermatol, 15:808-814.
89. Romero-Mendez IZ, Shi Y, HogenEsch H, Hem SL (2006) Potentiation of the immune response to non-adsorbed antigens by aluminum-containing adjuvants. Vaccine, in press.
90. Sokolovska A, Hem SL, HogenEsch H. Activation of dendritic cells and induction of CD4+ T cell differentiation by aluminum-containing adjuvants. Vaccine, 25:4575-4585, 2007